RUNX3

RUNX3

A gene on chromosome 1p36 that encodes a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and a beta subunit form a complex found in a number of enhancers and promoters, and together either activate or suppress transcription. RUNX3 is a tumour suppressor which also interacts with other transcription factors. 

Molecular pathology
RUNX3 deletion or transcriptional silence may be associated with cancer.
References in periodicals archive ?
During qRT-PCR assay, 8 genes including 5 enhanced genes (miR-205, miR-148a, miR-144, miR-30d, and Lcn2) (Figure 2) and 3 reduced genes (RunX3, Tns1, and Cnnm1) (Figure 2D), showed expression patterns similar to those observed in an integrated analysis.
The list of genes to explore is established on the basis of the differential expression in RA vs controls, and included four up-regulated genes (S100A8, PGLYRP1, RNASE2, and LY96) and two down-regulated genes (RUNX3 and IL2RB) (Ataee et al., 2015).
The oncogenic activation of [beta]-catenin and K-ras, amplification of the c-erbB2 and c-met genes, p53 and APC gene mutations, somatic mutations of E-cadherin, runt-related transcription factor 3 (RUNX3), and microsatellite instability (MSI) are associated with the pathogenesis of gastric cancer.
The genes responsible for the host's immune response by macrophage activation and NF-kB signaling are RUNX3, TAGAP and STAT3.
Additionally, several studies carried out in whole blood samples from DN patients have identified differentially methylated genes (NRBF2, RUNX3, DAPK3 UNC13B, and DOC2A) associated to different processes such as transcription regulation, inflammation, apoptosis, or exocytosis [35, 36].
Active EZH2 induces and activates, in conjunction with HMGA, tumour-promoting factors and proliferation, repressing differentiating factors such as runt-domain transcription 3 factor (RUNX3), p57 cyclin-CDK inhibitor 1C (CDKN1C), and cadherin 1 (CDH1) [28, 42-49].
We found the DMPs were located in the promoter regions of 12 genes (60%), including hypomethylated DMPs on seven upregulated genes (CSTA, CTSG, CTSZ, ELANE, LTBR, NFE2, and ODF3B) and hypermethylated DMPs on the five downregulated genes (CXCR6, FYN, PAG1, PRF1, and RUNX3).
Similarly, ITGB3 [51], Astrocyte Elevated Gene-1 (AEG-1) [8], metadherin (MTDH) [15], and RUNX3 [23], they are all connected with EMT that regulates cell invasion and migration through targeted miR30a.
It is testified that some major genes are actually involved in the malignant transformation of ovarian endometriosis; among these contributing genes, epigenetic inactivation of Runt-related transcription factor 3 (RUNX3) [18], human mutL homolog 1 (hMLH1) [19], E-cadherin (CDH1) [20], Ras-association domain family of gene 2 (RASSF2) [21], and P16 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) [22] by promoter hypermethylation was well observed; however, long interspersed nuclear element-1 (LINE-1) [23] and syncytin-1 [24] were hypo-methylated and activated.
The Runt-related transcription factor 3 (RUNX3) primers were as follows: forward, 5'-AGGCAATGACGAGAACTACTCC3' and reverse, 5'-CGAAGGTCGTTGAACCTGG-3'.