RPS6KA4

RPS6KA4

A gene on chromosome 11q11-q13 that encodes a p90 ribosomal S6  serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factor RELA. RPS6KA4 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it is thought to induce transcription of the MAP kinase phosphatase DUSP1 and IL10 (an anti-inflammatory cytokine) via CREB1 and ATF1 transcription factors.

Molecular pathology
Aberrant activation of p90 RSKs has been linked to breast and prostate cancers.
References in periodicals archive ?
alpha-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kappaB induction of RPS6KA4. Anticancer Drugs.
Among these, IL12A, IL12RB2, IRF5, TNPO3, DENND1B, SPIB, TNFAIP2, CXCR5, CLEC16A, RAD51L1, IRF8, RPS6KA4, MAP3K7IP1, TNFRSF1A, PLCL2, ELMO1, and ARF7 played an important role in the morbidity of PBC in European ancestries, while TNFSF15 and POU2AF1 were unique in Japanese ancestries, and CD80, IKZK3, Il7R, NFKB1, and STAT4 were proved to be associated with PBC in both races.
Chi, "[alpha]-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-[kappa]B induction of RPS6KA4," Anti-Cancer Drugs, vol.