RPS6KA4A gene on chromosome 11q11-q13 that encodes a p90 ribosomal S6 serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factor RELA. RPS6KA4 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it is thought to induce transcription of the MAP kinase phosphatase DUSP1 and IL10 (an anti-inflammatory cytokine) via CREB1 and ATF1 transcription factors.
Aberrant activation of p90 RSKs has been linked to breast and prostate cancers.
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