RPD3 | definition of RPD3 by Medical dictionary
HDAC1 (redirected from RPD3)
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HDAC1 A gene on chromosome 1p34 that encodes histone deacetylase 1, which belongs to the histone deacetylase/acuc/apha family and is a part of the histone deacetylase complex. It interacts with retinoblastoma tumour-suppressor protein and controls cell proliferation and differentiation. With metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
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References in periodicals archive
Miki, "Functional analysis ofa RPD3
histone deacetylase homologue in Arabidopsis thaliana," Plant Molecular Biology, vol.
Up to now, 18 human HDAC enzymes are characterized and classified into four classes: class I HDACs share sequence similarity with the yeast Rpd3
deacetylase; they are ubiquitously expressed and are localized in the nucleus.
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3
histone deacetylase to target promoters.