One trigger of the logic gate is the TME, and the other is the target antigen (AXL or ROR2
, depending on the product).
transmembrane protein tyrosine kinase is an onco-fetal protein that acts as a non-canonical Wnt 5A receptor.
(12,13) Under the pathological condition, the expression of Wnt5a and Ror2
The statistics show non-oil exports increased by 31.4 per cent to ROR2
,364.7mn, compared with RO1,799.6mn during the same period in 2016.
Several cell surface markers, including CD105, CD146, CD271, and receptor tyrosine kinase-like orphan receptor 2 (ROR2
), have been considered as markers of MSCs with high potential for chondrocyte differentiation [11-14].
In this pathway, a noncanonical Wnt ligand, such as Wnt5a, interacts with Fz2 and receptor tyrosine-like orphan receptor 2 (ROR2
) to activate Rac1.
Hojjat-Farsangi et al., "Orphan receptor tyrosine kinases ROR1 and ROR2
in hematological malignancies," Leukemia & Lymphoma, vol.
pylori are associated with cell cycle progression and proliferation (p14, p16, p21, p27, RAB40C, COX 2, FOS, ERBB2, FGFR2, ABL1, ECOP, JAK2, MYC, MET, SIRT1, PDCD4, TRAF6, GMNN, and CCNE2) [213, 223-242], apoptosis (RECK, SMAD4, TRAIL, MCL1, BIM, XIAP, and PDK1) [243-250], and invasion and metastasis (pTEN, WNT 5a, EDNRA, ROR2
, EPB41L3, MMP1, MMP10, HMGA2, ROBO1, TGF-[beta], EZH2, casein kinase 2, and ZEB) [251-262].
Ford, "Migration and invasion is inhibited by silencing ROR1 and ROR2
in chemoresistant ovarian cancer," Oncogenesis, vol.
Storti et al., "Myeloma cells inhibit non-canonical wnt co-receptor ror2
expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells," Leukemia, vol.
In order for Wnt5A to promote the phenotype switch from early in the tumor's formation to the time it becomes metastatic, the tyrosine kinase receptor ROR2
A total of 11.4% polymorphisms (25/220 SNPs) within the below listed 9 genes were found to have a statistically different distribution between cases and controls: NRC31, ANKH, VDR, ROR2
, CALCR, IL6, COL1A2, CBG, and LRP4.