Finally, we anticipate selecting a construct for IND-enabling studies of our ROR1
CAR-T program before the end of this year.'
is an integral transmembrane protein consisting of extracellular and intracellular conserved domains.
According to the company, NBE-002 is a best-in-class immune-stimulatory ADC (iADC) treatment against the ROR1
cancer target and is planned to enter into clinical trials in mid 2020 in triple negative breast cancer and other indications.
Furthermore, we identified disease terms by consulting with the GAD and identified 5 genes, i.e., ANK1, ROR1
, EEA1, PDCD6IP, and BRINP3 that were associated with LDL cholesterol.
Hudecek et al., "Safety of targeting ROR1
in primates with chimeric antigen receptor-modified T cells," Cancer Immunology Research, vol.
Zhou et al., "ROR1
is a novel prognostic biomarker in patients with lung adenocarcinoma," Scientific Reports, vol.
Xing et al., "A ROR1
-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis," Nature Cell Biology, vol.
Receptor tyrosine kinase-like orphan receptor 1 (ROR1
) is an oncofetal antigen expressed in a number of malignancies.
The anti-CSC compounds under clinical trials for other malignancies but not for bone sarcomas include ROR1
inhibitor, oncolytic adenovirus, and immunotherapy .
Ford, "Migration and invasion is inhibited by silencing ROR1
and ROR2 in chemoresistant ovarian cancer," Oncogenesis, vol.
En el cancer pulmonar se ha reportado hipometilacion de los genes MAGEA, TKTL1, BORIS, DDR1, TMSB10, ROR1
, entre otros (tabla 2) [13-17].