ROR1

ROR1

A gene on chromosome 1p32-p31 that encodes a tyrosine kinase belonging to the ROR subfamily of cell surface receptors, which modulates neurite growth in the CNS; its exact role is not known.
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En el cancer pulmonar se ha reportado hipometilacion de los genes MAGEA, TKTL1, BORIS, DDR1, TMSB10, ROR1, entre otros (tabla 2) [13-17].
Cytoskeleton network and cellular migration modulated by nuclear localized receptor tyrosine kinase ROR1.
The only other member of the family that has been identified is ROR1, and this research was done to determine what role ROR1 might play in the progression of melanoma.
The researchers were able to determine that ROR1 inhibited the invasion of melanoma cells, and this receptor was targeted for degradation by Wnt5A and ROR2.
When ROR1 was silenced, the researchers observed that there was an increased rate of invasion of melanoma cells both in vitro and in vivo.
Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid leukemias.
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.
The B-cell tumor associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.
Expression of ROR1 in patients with renal cancer-a potential diagnostic marker.
In this comparative study the expression profile of ROR1 mRNA was investigated in Iranian patients with CLL and Acute Myelogenous Leukemia (AML) and the results were compared with those previously reported in our Iranian ALL patients.
Keywords: Acute myelogenous leukemia, Chronic lymphocytic leukemia, ROR1, RT-PCR
ROR1 is a member of the family of tyrosine kinase receptors which is highly conserved among various species (1).