ROCK2

ROCK2

A gene on chromosome 2p24 that encodes a protein kinase which is a key regulator of actin cytoskeleton and cell polarity. It regulates smooth muscle contraction, actin cytoskeleton organisation, stress-fibre and focal adhesion formation, and neurite retraction, as well as cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, DPYSL2, EP300, EZR, IRF4, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A, SORL1 and VIM. It downregulates VEGF-induced angiogenesis.
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KD025 is a selective oral inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2), a signaling pathway that modulates inflammatory response.
MiR-142-3p attenuates the migration of CD4(+) Tcells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans.
The study will evaluate the efficacy and safety of KD025, Kadmon's ROCK2 inhibitor, in adults with cGVHD who have received at least two prior lines of systemic therapy.
The grant provides funding for milestone-driven research to assess the potential of BA-1049, a Rho Kinase 2 (ROCK2) inhibitor in BioAxone's pipeline, to improve recovery in chronic spinal cord injury.
The Rho-kinase (ROCK) pathway is involved in the process of proliferation in the human prostate, with reports indicating its suitability as an additional target for a more effective treatment strategy for BPH, whereby contractility and proliferation are targeted accordingly.[5] ROCK is a downstream effector of the Rho family GTPases, with two highly homologous isoforms, ROCK1 and ROCK2.[6] However, the molecular mechanism by which ROCK influences BPH still requires further elucidation.
Guo, "MiR-124 promote neurogenic transdifferentiation of adipose derived mesenchymal stromal cells partly through RhoA/ROCK1, but not ROCK2 signaling pathway," PloS One, vol.
Phosphorylation of the myosin phosphatase targeting subunit of MLCP (MYPT1) at T696 (human isoform numbering) by Rho-associated kinase (ROCK2) inhibits MLCP activity [11,12].
Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochimicaet Biophysica Acta 1853: 1606-1614.
Two isoforms, ROCK1 (also known as ROK[beta] or p160ROCK) and ROCK2 (known as ROK[alpha]), were isolated as Rho-A-GTP interacting proteins [6].
Lingor, "ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS," Cell Death & Disease, vol.
Signaling through S1PR4 in myoblasts involved activation of ROCK2, leading to phosphatase and tensin homolog (PTEN) phosphorylation and subsequent inhibition of protein kinase B (PKB/AKT) signaling.