ROCK1

A gene on chromosome 18q11.1 that encodes a protein kinase, which is a key regulator of actin cytoskeleton and cell polarity. It regulates smooth muscle contraction, actin cytoskeleton organisation, stress-fibre and focal adhesion formation, and neurite retraction, as well as cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. It phosphorylates FHOD1, and both promote SRC-dependent non-apoptotic plasma membrane blebbing. ROCK1 also: phosphorylates JIP3 and regulates JNK to JIP3 recruitment in response to UVB-induced stress; suppresses inflammatory cell migration by regulating PTEN phosphorylation and stability; downregulates VEGF-induced angiogenic endothelial cell activation; promotes keratinocyte terminal differentiation; and plays a role in terminal erythroid differentiation. ROCK1 is required for centrosome positioning and centrosome-dependent exit from mitosis. It may regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.

References in periodicals archive ?

Through the pathway maps, we identified alterations in the expression of Bmpr1a, Tgfbr1, Rock1 , and s p1 , which are involved in the TGF-[sz] signaling pathway [Table 2].

Estrogen-induced Tgfbr1 and Bmpr1a Expression Repressed via Estrogen Receptor Beta in MC3T3-E1 Cells

Transcription factor Sp1 promotes the expression of porcine ROCK1 gene.

Characterization of the porcine Nanog 5'-flanking region

This process was mediated by the activation of the death receptor 5 signaling pathway in hepatocytes with downstream activation of caspases and of Rho-associated coiled-coil containing protein kinase 1 (ROCK1) [126].

Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases

Several genes have been identified as targets of miR-340, including MITF (23), c-Met (12), ROCK1 (36), RhoA (37), Nrf2 (29), p27 (33), MYO10 (34), NRAS (28), MDM2 (35), NF-x03BA, and CTNNB1 (25).

MicroRNA-340-5p modulates cisplatin resistance by targeting LPAAT[beta] in osteosarcoma

Arabidopsis ROCK1 transports UDP-GlcNAc/UDP-GalNAc and regulates ER protein quality control and cytokinin activity.

The miRNAomes in Rehmannia glutinosa Roots Exposed to Different Levels of Replanting Disease Pressure

It has been demonstrated that CERK/C1P is involved in pancreatic cancer cell migration and invasion, and survival is dependent on phosphatidylinositol 3-kinase (PI3K) and ROCK1 pathways [141].

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Cho et al., "MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer," PLoS ONE, vol.

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

Two isoforms, ROCK1 (also known as ROK[beta] or p160ROCK) and ROCK2 (known as ROK[alpha]), were isolated as Rho-A-GTP interacting proteins [6].

Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases

[83] found that Drp1 at serine 600, as a substrate of Rho signal pathway, not only initiated mitochondrial ROS and podocyte apoptosis in high glucose but also was phosphorylated in ROCK1 knock-out mouse.

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

Ct values of targeted mRNA including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), RhoA, Rho-associated protein kinase 1 (ROCK1), ROCK2, and myosin light chain (MLC) were normalized according to the Ct values of GAPDH.

Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure

Results of this study are somewhat similar to findings of Singh, Hamdan and Rock1, which showed that AC picture 4 and above were assessed as needing orthodontic treatment by more than 50% of the subjects.

ORTHODONTIC TREATMENT NEED AS PERCEIVED BY UNIVERSITY STUDENTS USING AESTHETIC COMPONENT (AC) OF INDEX OF ORTHODONTIC TREATMENT NEED (IOTN)

miRNAs Blanco asociado Funcion del miRNA en metastasis de tumor miR-10b HOXD10 Promotor miR-21 PTEN, PDCD4, TPM1, Maspin Promotor miR-373 CD44, LATS2 Promotor miR-520c CD44 Promotor miR-155 RhoA Promotor Let-7 Ras, HMGA2 Represor miR-335 SOX4, TNC Represor miR-126 Crk, IRS-1 Represor miR-146a ROCK1 Represor miR-101 EZH2 Represor Familia miR-200 ZEB1, ZEB2 Represor