RNA replicase


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RNA replicase

An enzyme that catalyses the synthesis of RNA, using RNA as a template. The enzyme is used by RNA viruses for their replication within a cell.
References in periodicals archive ?
Another pair of primers, FLV1/FLV2, was designed to hybridize to conserved regions within the RNA replicase (NS5) gene of a wide variety of flaviviruses, amplifying nearly a 220-bp fragment (FLV1, 5'-GGI, AGC, AGI, GCC, ATI, TGG, T(A/T)C, ATG, TGG - 3'; FLV-2, 5'-C(G/T)I, GTG, TCC, CAI, CCI, GCI, GTG, TCA, TC-3').
Furthermore, the broad substrate specificity of the RNA suggests that it might be made the catalytic subunit in a series of ribozymes, the specificities of which are determined by a second RNA to constitute, for example, a multimeric RNA replicase.
WEINER: Your ability to make a real RNA replicase is absolutely amazing, but it doesn't keep going and going and going.