RNA processing

RNA processing

processes involved in the formation of mature, fully functional RNA species from primary RNA transcripts. For eukaryotic mRNA this may involve the removal of INTRONS (RNA splicing) and the addition of a cap at the 5′-end (See CAPPING (1)) and of a Poly(A) tail (see POLYADENYLATION). Generally little modification is made to prokaryotic mRNA; rRNA and tRNA in PROKARYOTES and EUKARYOTES are both modified. Both are cut out of large primary transcripts. For tRNA some of the bases are modified chemically. These processes occurring after TRANSCRIPTION are also called POSTTRANSCRIPTIONAL MODIFICATIONS.
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This, in turn, will place the institute in lisbon within the core of european laboratories that are carrying on frontier research on how transcription and rna processing shape and define the complexity of human disease.
Antisense oligonucleotides, used in the above study, were found to influence RNA processing and modulate protein expression over 20 years ago and much progress has been made translating these agents into a clinical setting.
Sharir is also proficient in the development, optimization and implementation of high-throughput screening and high-content screening assessments approaches to cell biology that are used for large-scale applications.<br />Kfir has a background in molecular genetics and specializes in RNA processing and chromatin organization.
IGF2BP2 in RNA Processing. Our knowledge about the functions of IGF2BPs in RNA processing mainly comes from the studies on IGF2BP1, the best understood member of this RBP family.
Hortobagyi et al., "Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6," Science, vol.
TDRD4/ring finger protein 17 (RNF17) and TDRD5 are mainly expressed in chromatoid bodies and involved in RNA processing for spermatogenesis (Smith et al., 2004; Pan et al., 2005).
Their topics include: to the cell and beyond, the realm of molecular genetics, nucleic acids, principles and applications of recombinant DNA, the physical structure of the genomic material, transcription in eukaryotes, the regulation of transcription in bacteria, RNA processing, the players and process of translation, protein processing and modification, DNA replication in bacteria and eukaryotes, and DNA repair.
The CBC remains bound to the cap during RNA processing and has an active role in both splicing and RNA export.
The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing and movement, which are often altered in disease.
Furthermore, because RNA molecules can interact with DNA, RNAs, proteins, and small molecules, RNA-based therapeutics may also provide the flexibility and specificity necessary to selectively manipulate intricate profiles of gene transcription, posttranscriptional RNA processing, and translation by targeting epigenetic effectors such as nucleosome- and chromatin-remodeling complexes, multiple ncRNAs (e.g., miRNAs and lncRNAs), and RNA editing and DNA recoding enzymes.
On the other hand, the fact that c.2002 -2 A>T mutation is only two bases away from the region of RNA processing shows that this mutation can cause abnormal protein formation by affecting RNA processing and this genotype can be associated with the phenotype.
Reduced RNA processing inhibited the translation of proteins required to maintain the mitochondrial electron transport chain that consumes oxygen during cell respiration to produce energy.