Antisense oligonucleotides, used in the above study, were found to influence RNA processing
and modulate protein expression over 20 years ago and much progress has been made translating these agents into a clinical setting.
Sharir is also proficient in the development, optimization and implementation of high-throughput screening and high-content screening assessments approaches to cell biology that are used for large-scale applications.<br />Kfir has a background in molecular genetics and specializes in RNA processing
and chromatin organization.
IGF2BP2 in RNA Processing
. Our knowledge about the functions of IGF2BPs in RNA processing
mainly comes from the studies on IGF2BP1, the best understood member of this RBP family.
Hortobagyi et al., "Mutations in FUS, an RNA processing
protein, cause familial amyotrophic lateral sclerosis type 6," Science, vol.
TDRD4/ring finger protein 17 (RNF17) and TDRD5 are mainly expressed in chromatoid bodies and involved in RNA processing
for spermatogenesis (Smith et al., 2004; Pan et al., 2005).
Their topics include: to the cell and beyond, the realm of molecular genetics, nucleic acids, principles and applications of recombinant DNA, the physical structure of the genomic material, transcription in eukaryotes, the regulation of transcription in bacteria, RNA processing
, the players and process of translation, protein processing and modification, DNA replication in bacteria and eukaryotes, and DNA repair.
The CBC remains bound to the cap during RNA processing
and has an active role in both splicing and RNA export.
The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing
and movement, which are often altered in disease.
Furthermore, because RNA molecules can interact with DNA, RNAs, proteins, and small molecules, RNA-based therapeutics may also provide the flexibility and specificity necessary to selectively manipulate intricate profiles of gene transcription, posttranscriptional RNA processing
, and translation by targeting epigenetic effectors such as nucleosome- and chromatin-remodeling complexes, multiple ncRNAs (e.g., miRNAs and lncRNAs), and RNA editing and DNA recoding enzymes.
On the other hand, the fact that c.2002 -2 A>T mutation is only two bases away from the region of RNA processing
shows that this mutation can cause abnormal protein formation by affecting RNA processing
and this genotype can be associated with the phenotype.
Reduced RNA processing
inhibited the translation of proteins required to maintain the mitochondrial electron transport chain that consumes oxygen during cell respiration to produce energy.