RNA interference


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to RNA interference: Sirna

RNA interference

n. Abbr. RNAi
A process in which double-stranded RNA inhibits the expression of genes by triggering degradation of messenger RNAs with complementary sequences.

RNA interference

,

RNAi

The blocking of gene expression by disrupting the translation of messenger RNA into proteins. Synonym: posttranscriptional gene silencing
References in periodicals archive ?
RNA interference (RNAi) has emerged as a leading therapeutic strategy in oncogene therapy applications (Mello and Conti, 2004; Kim and Rossi, 2007).
"RNA interference holds a huge amount of promise for a number of disorders, one of which is cancer, but also neurological disorders and immune disorders," she says.
"Our challenge with RNA interference technology is to figure out how to deliver it into the human brain in a sustained, safe and effective manner," said Nolta.
Benitec Limited (ASX:BLT) (PINK:BNIKF) holds a dominant position in expressed RNA interference (RNAi)-based human therapeutics, with a transformational platform technology supported by a robust and extensive intellectual property portfolio.
of Western Ontario, Canada) and Ichim, an industry immunologist, compile 27 chapters describing current science and protocols in RNA interference (RNAi) for disciplines from detailed nucleic acid chemistry to pharmacology to manipulation of signal transduction pathways.
RXi Pharmaceuticals is a discovery-stage biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi) for the treatment of human diseases.
RXi Pharmaceuticals Corporation (Nasdaq: RXII), Worcester, Mass., a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), has recently acquired direct ownership of technology for which it had previously exercised its option to exclusively license from Advirna LLC.
A $6 million grant to the medical school from the National Institutes for Health will fund more research into RNA interference, a line of research that attempts to "silence" specific genes that cause disease.
They then tested the activity of the 100 most promising candidates with a scientific technique called RNA interference (RNAi).
IS RNA INTERFERENCE INVOLVED IN PLANT-FUNGAL SYMBIOSIS?
KEY WORDS: Alcohol and other drug disorder (AODD); genetic theory of AOD use (AODU), brain; genetics and heredity; gene knockout technology; RNA interference (RNAi), small hairpin RNAS (shRNAs), viral delivery systems; lentivirus; oligonucleotides