RNA World Hypothesis

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A conceptual era in Earth’s early evolution in which life began as biologically active, self-replicating molecules—catalytic RNA—that were later assisted by crude polypeptides See Primordial soup, Urkingdom
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The emergence of such enzymes in a primordial RNA world -- which the new study shows was plausible -- could have overcome a key obstacle to the origin of life.
Relevant (but inadequate) Critiques: Metabolism First and the RNA World
But the proposal now needs evidence to back it up, and some researchers point out that no one has been able to make the ribozyme, a key player in the RNA world, grab the specific amino acids that match up with its nucleotides.
of Colorado) to reject the title The RNA World, 4th edition in favor of RNA Worlds in recognition of the importance of these present day RNA molecules to present-day biology and to investigating the RNA World hypothesis.
In addition to discussion of chemical evolution, the RNA world, Darwinian evolution, and the endosymbiotic theory for the evolution of eukaryotes, there is a chapter on sociobiology where we learn about the social behavior of Dictyostelium, Caenorhabditis, rodents, and humans.
If this RNA world hypothesis is true, RNA must necessarily be a versatile molecule, capable of carrying out all of the metabolic functions necessary to sustain the earliest life forms.
9) According to the RNA World Hypothesis, the first living system was a polymer(s) of catalytic RNA capable of self-replication that subsequently evolved the ability to encode more versatile peptide catalysts.
For example, the RNA World Databases site of the Institut fur Molekulare Biotechnologie in Jena, Germany, provides access to a vast wealth of databases, web-based tools, and software.
However, we believe that the second mechanism may be advantageous to synthesize large RNA by primitive catalytic RNA, and ribozymes with RNA ligation activity might have been an essential catalytic activity in t he RNA world.
The research supports the view that life began in an RNA world and Dna-based things evolved later.
It is against this background that the contributions cover such a wide range of theories, including chemistry and selection, evolution of the pioneer organism, chemical aspects of synthetic biology, ribozyme catalysis of metabolism in the RNA world, intractable mixtures and the origin of life, the chemical etiology of nucleic acids, interstellar amino acids, and even the chemistry that preceded life's origin.
The RNA world hypothesis is extremely unlikely," said Carter.