PRDM2

(redirected from RIZ1)

PRDM2

A gene on chromosome 1p36.21 that encodes a tumour suppressor zinc finger protein of the nuclear histone/protein methyltransferase superfamily, which binds to the retinoblastoma protein, oestrogen receptor and the TPA-responsive element (MTE) of the haeme-oxygenase-1 gene. PRDM2 may:
• Play a role in regulating transcription during neuronal differentiation;
• Activate transcription of the haeme-oxygenase-1 gene;
• Be a specific effector of oestrogen activty.

Molecular pathology
PRDM2 activation may be linked to retinoblastoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Other frequently methylated genes in HCC include RIZ1 (45.2%), CDKN2A (69.7%), SCARA5 (30%), EFEMP1 (50%), TIP30 (47%), WIFI, FBLN1 (50%), DLEC1 (70.6%), FBP1 (80%), ITGA4 (23%), KLK10 (94%), LIFR (47.9%), MTIG (60.4%), HHIP (53.6%), HINT1 (55%), SYK (12%), and TAT (54%) [18, 19].
(37) These additional 188 AAs in MECOM have about 40% homology with the PR (PRDIBF1/Blimp-1 and RIZ1) domain of the retinoblastomainteracting zinc-finger protein (RIZ).
Aberrant methylation of the RIZ1 gene in myelodysplastic syndrome and acute myeloid leukemia.
Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.
Ding, "Detecting abnormal methylation of tumor suppressor genes GSTP1, P16, RIZ1, and RASSF1A in hepatocellular carcinoma and its clinical significance," Oncology Letters, vol.