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RIPK2A gene on chromosome 8q21 that encodes a serine/threonine/tyrosine kinase which is intimately involved in modulating innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerise, and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes “Lys-63”-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein then recruits MAP3K7/TAK1 to IKBKG/NEMO, induces “Lys-63”-linked polyubiquitination of IKBKG/NEMO and activates IKBKB/IKKB.
In turn, NF-kappaB is released from NF-kappaB inhibitors and translocates to the nucleus, where it activates transcription of myriad genes involved in immune response, growth control or anti-apoptosis. It also plays a role during engagement of the T-cell receptor in promoting BCL10 phosphorylation and subsequent NF-kappaB activation.