RIPK1

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RIPK1

A gene on chromosome 6p25.2 that encodes a serine/threonine/tyrosine kinase which transduces inflammatory and cell-death signals (necroptosis), triggered in response to the binding of ligands to death receptors, activation of pathogen recognition receptors (PRRs) and DNA damage. Activation of TNFR1 by TNF-alpha family cytokines recruits TRADD and TRAF2 to the receptor; ubiquitination by TRAF2 enhances communication with downstream signal transducers in the mitogen-activated protein kinase (MAPK) and NF-kappaB pathways, activating genes that encode inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappaB activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 form a necroptosis-inducing complex.
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References in periodicals archive ?
As a gatekeeper of mPTP, CypD, which mediated mPTP opening, may contribute to not only apoptosis but also necroptotic cell death in cerebral I/R injury and alleviated the levels of RIP1 and RIP3 [34].
degradation and necrosome formation via suppression of RIP1, which prevents unrestrained production of proinflammatory cytokines and cell death in myocardium, thus improving myocardial function during sepsis.
"We started investigating RIP1 from a perspective of necrotic cell death before finding that it actually plays an important role in regulating melanoma cell survival ...
"Our study identifies a new mechanism involving RIP1 that regulates cell division and death in glioblastomas," says neurologist and senior author Amyn Habib.
Under conditions that are insufficient to trigger apoptosis, TNF[alpha] activates TNFR1 and in turn induces the recruitment of receptor-interacting protein 1 (RIP1) kinase and other proteins to form complex I.
The findings show that the protein RIP1 acts as a mediator of brain tumor cell survival, either protecting or destroying cells.
But resveratrol, a phytochemical found in red grapes, has a different set of what Hwang refers to as "molecular targets." His experiments suggest that resveratrol interferes with molecules called "TBK1" and "RIP1." Normally, these molecules help convey signals to and from TLRs.
Access router features include RIP1 and RIP2 static and dynamic routing, and security through access lists Network monitoring capabilities include end-to-end performances monitoring in support of QoS statistics through, in-band management, RMON-2 and IP SLA verification, p lus a broad set of trouble shooting diagnostics.
The product supports TCP/IP with RIP1, RIP1-compatible and RIP2, static routing on the LAN and/or WAN, Novell IPX with RIP/SAR DNS relay, multiple ethernet subnets on the LAN, virtual routes, and PPP over Ethernet.-Efficient Networks
It was reported that TNF-[alpha] may activate receptor interacting protein 1 (RIP1) to induce NF-[kappa]B activation, which is followed by initiation of p65/p50 transactivation and finally induction of MMP expression [34].
Aside from NEMO, other targets of polyubiquitin downstream of TLR activation have been described as negatively regulated by TNIP1 including TANK-binding kinase 1 (TBK1) [59], receptor-interacting serine/threonine kinase 1 (RIP1 or RIPK1) [41], and interleukin-1 receptor-associated kinase 1 (IRAK1) [42].
Antibodies for PARP, cleaved PARP, caspase 3, caspase 9, RIP1, MLKL, Beclin, p62, and peroxidase-conjugated secondary antibody were purchased from Cell Signaling (Danvers, MA).