TAP1

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TAP1

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance. TAP1 pumps degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment.

Molecular pathology
TAP1 mutations have been tentatively linked to ankylosing spondylitis, type 1 diabetes and coeliac disease.
References in periodicals archive ?
The IT of P1 (first positive peak) and amplitudes (N1-P1) were analyzed for the specified areas in five rings including ring1, ring2, ring3, ring4, and ring5.
Other locational factors include the school district in which the home is located (from SD1 to SD24) and the distance (RING1 to RING4) from the central city district of San Antonio.
RING4 properties are those properties with zip codes outside Highway 1604 but within the boundaries of Bexar County.