TGFBR2

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TGFBR2

A gene on chromosome 3p22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-I TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR2 mutations are associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and development of various tumours.
References in periodicals archive ?
The RIIC's user base includes over 1,200 local, state and federal law enforcement partners across both Lehigh and Northampton Counties within the Eastern District of Pennsylvania.
The development of the RIIC Gang Intelligence Data Base was funded through the PCCD, the Trexler Trust, and forfeiture money provided by District Attorney Martin.
Villanueva further stressed that the RIIC will revitalize the tempo of our economic activities and of course, reduce regional inequalities and usher socioeconomic development in Central Luzon.
Kanye Administrative Authority chairperson, Mr Tlhomamo Dibeela, expressed gratitude that BITRI had partnered with former RIIC employees.
It can also appoint any person it deems important in facilitating RIIC's mission.
RIIC, which we plan to change into Regional Investment and Commercial Hub (RICH), aims to optimize the use of available infrastructures and the available resources, both natural and human, to entice investors into the region.
(RIIC) to make Central Luzon the country's leading business center.