TGFBR2

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TGFBR2

A gene on chromosome 3p22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-I TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR2 mutations are associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and development of various tumours.
References in periodicals archive ?
This installation will give RIIC a seamless solution to enhance their services for years to come.
He added, "For a freestanding imaging center such as RIIC, this is a great advantage for the organization to overcome challenges and deliver efficiencies that contribute to the bottom line.