PRKAR2B

(redirected from RII-BETA)

PRKAR2B

A gene on chromosome 7q22 that encodes one of the regulatory subunits of cAMP-dependent protein kinase, which transduces activating signals by phosphorylating different target proteins. PRKAR2B interacts with cAMP-responsive element-binding protein 1 (CREB1) in activated T cells and suppresses transcription. Knockout studies in mice suggest that PRKAR2B may play a role in regulating energy balance and adiposity.
References in periodicals archive ?
The missing mouse gene encodes an enzyme subunit, called RII-beta. The enzyme, PKA, comes in several versions, and the one with RII-beta is largely made by brain and fat cells.
Compared to RII-beta, RI-alpha binds more easily to certain signaling molecules, so PKA is more readily activated in the mice.
Other than their enviable leanness, the mice lacking RII-beta seem ordinary.