INSL6

(redirected from RIF1)

INSL6

A gene on chromosome 9p24 that encodes insulin-like 6 protein, a member of the insulin superfamily, which is thought to have a role in sperm development and fertilisation.
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The top 10 transcripts with the lowest pointwise p value (p <0.01) for the difference in the expression level between HHP-treated and untreated eggs encompassed transport protein Sec31A-like Oreochromis niloticus homolog, insulin-like growth factor 1b receptor Oncorhynchus kisutch homolog, telomere-associated protein RIF1 Oreo-chromis niloticus homolog, IGF-I receptor subtype A, FH1/ FH2 domain-containing protein 3 (Danio rerio homolog), domain-containing glycophosphatidylinositol anchor protein, centromere protein F (Oreochromic niloticus homolog), FH1/FH2 domain-containing protein 3 (Oreochromis niloticus homolog), histone-lysine N-methyltransferase SETD2-like (Oreochromis niloticus homolog), and male-specific lethal 3-like 1 (Salmo salar homolog) (Table 2, Supplementary File Data).
These genes are involved in the regulation of development and somatic growth (la IGF1RB and lb IGF1RB, IGF-I receptor subtype A) [26], response to the DNA damage and regulation of the DNA mismatch repair (SETD2, RIF1) [27, 28], actin filament polymerization (FH1/FH2 domain-containing protein 3, (FHOD3)), transcriptional regulation (male-specific lethal 3-like 1 (MS3L1)), and formation of centromere/kinetochore complex (centromere protein F (CENPF)) [29] (Table 2, Supplementary File Data).
Stem cell proliferation marker signal transducer and activator of transcription 3 (STAT3) was enhanced, while replication timing regulatory factor 1 (RIF1) was downregulated.
Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader.
While conducting further experiments, researchers identified two genes - Rap1 and Rif1 that play a major role in mediating between telomere length and environmental stressors.
Expression of markers involved in the regulation of cell growth, proliferation, and DNA repair mechanism such as RIF1 and SET was downregulated, while SKIL expression was upregulated at P15 in hPDLSCs, hDPSCs, and hGMSCs.
After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replication-timing establishment.