RHOA


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RHOA

A gene on chromosome 3p21.3 that encodes a protein with multiple functions: it regulates a signal transduction pathway, linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibres; it is involved in a microtubule-dependent signal required for myosin contractile ring formation during cell cycle cytokinesis; it plays an essential role in cleavage furrow formation; and it is required for the apical junction formation of keratinocyte cell-cell adhesion. RHOA is activated by ARHGEF2, which promotes GDP for GTP exchange, and is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signalling pathway plays a key role in ERBB2-dependent stabilisation of microtubules at the cell cortex. It controls the localisation of APC and CLASP2 to the cell membrane by regulating GSK3B activity; membrane-bound APC allows the localisation of the MACF1 to the cell membrane, as required for microtubule capture and stabilisation.
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Furthermore, by modulating the activity of RhoA it is possible to change the lineage commitment.
Elbediwy et al., "Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis," Nature Cell Biology, vol.
Though AM966 is a competitive antagonist of the LPA1 receptor, here we show that AM966 induces biological effects in HLMVECs including phosphorylation of VE-cadherin and MLC, activation of RhoA, and reduction of TEER.
The effects of QSKL on the MAPK and RhoA pathways were studied in order to reveal the antifibrotic mechanisms of QSKL and offer an alternative approach for the clinical treatment of myocardial fibrosis.
Here we demonstrated that the intensity of RhoA phosphorylation in [Ser.sup.188] was halved in the kidneys of hypercalorically fed mice when compared to chow fed mice (Figure 7(a)), thus indicating a diet-dependent massive increase of RhoA pathway activity.
Based on this strong experimental evidence, the aims of the present study were to examine the correlations between RhoA activity and DNA damage and repair under genotoxic stress promoted by radiation consisting of each one of the three UV wavelengths (A, B, or C) and to determine whether the modulation of RhoA impacts on the motility, invasiveness, and proliferation of human melanoma cell lines.
Mechanical strain and hypoxia are known to activate the RhoA/ROCK pathway in many studies (23,24) and our MSC-treated animals exhibited significantly lower RhoA mRNA expression after 14 days of pBOO.
Kandi and Todd don't know whether they are going to have a boy or girl, but have announced their happy news, with the mum-to-be sharing with her RHOA co-stars, who are all so excited for her.
Jackson, comedian; and RHOA's Kim Zolciak-Biermann celebrate Bravo's upcoming series, NeNe and Kim: The Road to Riches.
In addition, our data showed that RhoA expression in rat aortas was increased by PugNAc (Figure 3D).
Phosphorylation of Cofilin-1 on Serine-3 is known to block these activities, which is regulated by RhoA GTPases through mTORC1-RhoALimk-Cofilin-1 pathways [8, 9].
Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine, said that high levels of RhoA and ROCK1 were known to worsen outcomes for breast cancer patients by endowing cancer cells with the ability to move, but the trigger for their production was a mystery.