RHOA

A gene on chromosome 3p21.3 that encodes a protein with multiple functions: it regulates a signal transduction pathway, linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibres; it is involved in a microtubule-dependent signal required for myosin contractile ring formation during cell cycle cytokinesis; it plays an essential role in cleavage furrow formation; and it is required for the apical junction formation of keratinocyte cell-cell adhesion. RHOA is activated by ARHGEF2, which promotes GDP for GTP exchange, and is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signalling pathway plays a key role in ERBB2-dependent stabilisation of microtubules at the cell cortex. It controls the localisation of APC and CLASP2 to the cell membrane by regulating GSK3B activity; membrane-bound APC allows the localisation of the MACF1 to the cell membrane, as required for microtubule capture and stabilisation.

Mentioned in ?

References in periodicals archive ?

2006) Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.

Structure and function of helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.

Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms

Finally, another recent study showed that a pool of chromosomal passenger complex (CPC)-regulated and membrane-bound centralspindlin can activate RhoA at the ingression site via oligomerization (Basant et al.

Central spindle self-organization and cytokinesis in artificially activated sea urchin eggs

List of PCR primers sequences Gene Forward sequence GRP78 5'-CCAGCTTACTTCAATGATGCAC-3' RhoA 5'-AGGACCAGTTCCCAGAGGTT-3' TGF[beta]1 5'-GAGGTGACCTGGGCACCAT-3' HIF1[alpha] 5'-TGCTTGGTGCTGATTTGTGA-3' Gene Reverse sequence GRP78 5'-CTTCTCTCCCTCTCTCTTATCC-3' RhoA 5'-ACTATCAGGGCTGTCGATGG-3' TGF[beta]1 5'-GGCCATGAGGAGCAGGAA-3' HIF1[alpha] 5'-GGTCAGATGATCAGAGTCCA-3'

Benefits of mesenchymal stem cells after partial bladder outlet obstruction

Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma.

Transicion epitelio-mesenquima y migracion celular en celulas de la cresta neural y celulas metastasicas de carcinomas. Revision de la literatura

The proteins RhoA and ROCK1 are known to be central to the formation of these structures.

Mechanism behind breast cancer's spread revealed

Researchers from Cincinnati Children's Hospital Medical Center focus on a protein called RhoA, a GTPase that serves as a molecular switch in the cytoplasm of cells to control cell function.

Study identifies essential molecule in formation of differentiated blood cells

p120 represses the activity of small GTPases of the Rho family (77), such as RhoA, to stabilize adhesion complexes.

Transicion epitelio-mesenquimatica (TEM): principios e impacto clinico en la terapia contra el cancer

Human urotensin ii-induced contraction and arterial smooth muscle cell proliferation are mediated by rhoa and rhokinase.

Effects of urotensin II and its specific receptor antagonist urantide on rat vascular smooth muscle cells

Differential effects of RhoA signaling on anticancer agent-induced cell death, Oncol Rep 13(2):299-304.

Efectos antitumorales de la simvastatina sobre la linea cellular de osteosarcoma UMR-106

A constitutively active RhoA directly stimulated NF-[kappa]B binding activity, BK-mediated IL-1[beta] synthesis results from RhoA-dependent NF-[kappa]B activation.

Activation of NF-[kappa] B signalling pathway by inflammatory regulators and associated drug discovering

The three main Rho GTPases are Rac1, Cdc42 and RhoA, and each has been shown to be specifically involved in lamellipodia formation, filopodia formation and stress fiber formation respectively (3,7).