RFX1

RFX1

A gene on chromosome 19p13.1 that belongs to the regulatory factor X gene family, which encode transcription factors that contain a highly conserved winged-helix DNA-binding domain. RFX1 is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other regulatory factor (RF) family members—RFX2, RFX3 and RFX5 (but not with RFX4)—binding specifically to the X-boxes of MHC class-II genes, which is essential for the expression of MHC II genes. It can also bind to an inverted repeat (ENH1), which is required for expression of hepatitis B virus genes.
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Regulatory factor X-box 1 (RFX1), which interacts with HDAC1 and SUV39H1, is downregulated in SLE [101, 102].
Gao et al., "Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells," Journal of Autoimmunity, vol.
In a recent study which aimed to unravel the mechanism of DNA hypomethylation of T lymphocytes in patients with SLE, a transcription factor named regulatory factor X1 (RFX1), which functions to recruit DNMT1 to the promoter region of CD70, was shown to be downregulated in human lupus CD4+ T cells, potentially contributing to CD70 overexpression [55].