restriction fragment length polymorphism

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re·stric·tion frag·ment length pol·y·mor·phism (RFLP),

used in genetic analysis of populations or individual relationships. In regions of the human genome not coding for proteins, the distance (in nucleotides on the chromosome) can be different between two genetic markers, usually because of repeated base patterns.
Farlex Partner Medical Dictionary © Farlex 2012

re·stric·tion frag·ment length pol·y·mor·phism

(RFLP) (rĕ-strik'shŭn frag'mĕnt length pol'ē-mōrf'izm)
Used in genetic analysis of populations or individual relationships. In regions of the human genome not coding for proteins there is often wide (but measurable) sequence variety between people.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

restriction fragment length polymorphism (RFLP)

Variations within a species in the lengths of fragments of DNA caused by RESTRICTION ENZYMES. The variations are caused by mutations that either abolish the normal sites of breakage or create new ones, characteristic of the mutations. RFLP analysis may allow genetic abnormalities to be detected, often before birth, even if the location of the mutated gene or genes is unknown.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

restriction fragment length polymorphism (RFLP)

a MUTATION that results in a change in the pattern of restriction fragments generated when a DNA molecule is treated with a RESTRICTION ENZYME (see RESTRICTION ANALYSIS). The RFLP is apparent when the fragments are resolved by AGAROSE GEL ELECTROPHORESIS. RFLPs can be used as reference LOCI for mapping, in relation to specific linked genes (see GENETIC LINKAGE). RFLPs can be used as a diagnostic test for genetic DISEASES, by detecting specific gene defects. The presence of the RFLP may be a direct indication of the gene defect, or may be closely linked to it. Diseases that have heen diagnosed by RFLP analysis include certain types of THALASSAEMIA and HAEMOPHILIA, and by RFLP linkage analysis, HUNTINGTON'S CHOREA.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
RFLP mapping of a brown planthopper (Nilaparvata lugens Stal) resistance gene bph2 of indica rice introgressed into japonica breeding line `Norin-PL4'.
The molecular basis of [C.sub.4] photosynthesis in sorghum: Isolation, characterization and RFLP mapping of mesophyll- and bundle-sheath-specific cDNAs obtained by differential screening.
RFLP mapping in maize: Quantitative trait loci affecting testcross performance of elite Eropean flint lines.
RFLP mapping of QTLs for resistance to European corn borer in maize.
RFLP Mapping in plant breeding: New tools for an old science.
RFLP mapping of genes conferring complete and partial resistance to blast in a durably resistant rice cultivar.
RFLP mapping data were collected from filters containing DNA from both parental genotypes and 126 individuals of the progeny.
RFLP mapping of resistance to southern root-knot nematode in soybean.
RFLP mapping of resistance to the blackleg disease [causal agent, Leptosphaeria maculans (Desm.) Ces.