RETN


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RETN

A gene on chromosome 19p13.2 that encodes resistin, which is secreted by adipocytes and suppresses insulin-driven glucose uptake by adipose cells.

Molecular pathology
RETN mutations may link obesity to type-2 diabetes.
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(9) suggests that monocytes and macrophages that are present in chronic periodontal disease may be the major source of RETN following stimulation by pro--inflammatory cytokines in periodontal tissues.
The aims of this study were: i) to determine six common single nucleotide polymorphisms (SNPs) in the genes that encode ADIPOQ, LEP and its receptor (LEPR), and RETN, ii) to analyse adipokine plasma levels in subgroups of systemically healthy individuals with or without CP and individuals with both T2DM and CP to investigate the possible impacts of these adipokines on the etiopathogenesis of CP.
Conclusions: Human resistin gene RETN C-420G single nucleotide polymorphism was found to be a risk factor for type 2 diabetes in Pakistani Punjabi Rajput population.
Keywords: Diabetes mellitus, Resistin, Single nucleotide polymorphism, RETN C-420G, Body mass index.
The primary goal of our study was to estimate the impact of RETN polymorphisms rs1862513 and rs3745368 and their haplotypes on MetS and its individual components in a Northeastern Chinese population.
According to previous studies [13, 15, 22], SNPs rs1862513 and rs3745368 were selected by the Haploview program (https://www.ncbi.nlm .nih.gov/gene/) to identify the association between RETN gene polymorphism and MetS.
RETN, which operates a backbone that stretches over 30,000 kilometres of fibre and connects 26 countries across Europe, Asia and North America, has selected the Infinera DTN-X to power its network core and its crucial points of presence that are located in Europe.
According to Infinera, its Intelligent Transport Network, featuring the DTN-X platform, enables RETN to differentiate its service offerings and increase network efficiency as it scales network capacity across its extensive Pan-European backbone.
Based on our microarray analysis, 14 genes, including three antimicrobial peptides (LEAP2, LOC396871, and MS4A2), two proteins involved in the regulation of proliferation and apoptosis of epithelial cells (PIAP and AREG), and genes associated with a number of physiological and metabolic processes (ATRN, CD59, CLU, DPEP1, EPHX1, RETN and UBP) were selected.