RET oncogene

RET oncogene

A proto-oncogene on chromosome 10 that codes for one of the tyrosine kinase receptors. Several mutations are known and all of them are associated with thyroid tumours. A number of children living in the Chernobyl region at the time of the power station disaster have been found to have rearrangements of the RET oncogene. Thyroid cancers, normally very rare in children are now occurring much more frequently than usual.
References in periodicals archive ?
Ret oncogene activation in thyroid neoplasms is restricted to the papillary cancer subtype.
Chang, "Bilateral adrenal pheochromocytoma with a germline L790F mutation in the RET oncogene," Journal of the Korean Surgical Society, vol.
RET oncogene was positive for our patient as D631Y mutation.
Romei et al., "Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer.
Molecular diagnostics company Biocept (NasdaqCM:BIOC) revealed on Thursday the market availability of its test to detect RET oncogene fusions from a simple blood draw in patients with lung cancer.
In addition to the EGFR, KRAS and BRAF tests, the company has kits for detecting mutations in JAK2, KIT, BCR-ABL, PIK3CA, EML4-ALK, P53 and the RET oncogene. Quantitative gene expression assays for excision repair (ERCC1), thymidine phosphorylase (TYMP), stathmin (STMN1), ribonucleotide reductase (RRM1) and other genes provide valuable information to help predict chemotherapy responses.
[sup][19] Perturbed DNA topoisomerase I activity can affect fragile-site breakage at the RET oncogene. [sup][20] The topoisomerase I inhibitor topotecan may stabilize the fragile-site breakage of the RET oncogene and render cancer cells more sensitive to chemotherapy.
Romei et al., "Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a10-year follow-up study," The Journal of Clinical Endocrinology & Metabolism, vol.
The protein - ASCL1 - is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET.
RET oncogene activation in papillary thyroid carcinoma.
Molecular defects in thyroid carcinomas: role of the RET oncogene in thyroid neoplastic transformation.
(1,2) The results of studies of RET oncogene expression further support the classification of WALTT as a papillary thyroid carcinoma.