RET oncogene

RET oncogene

A proto-oncogene on chromosome 10 that codes for one of the tyrosine kinase receptors. Several mutations are known and all of them are associated with thyroid tumours. A number of children living in the Chernobyl region at the time of the power station disaster have been found to have rearrangements of the RET oncogene. Thyroid cancers, normally very rare in children are now occurring much more frequently than usual.
References in periodicals archive ?
Molecular diagnostics company Biocept (NasdaqCM:BIOC) revealed on Thursday the market availability of its test to detect RET oncogene fusions from a simple blood draw in patients with lung cancer.
In addition to the EGFR, KRAS and BRAF tests, the company has kits for detecting mutations in JAK2, KIT, BCR-ABL, PIK3CA, EML4-ALK, P53 and the RET oncogene.
sup][20] The topoisomerase I inhibitor topotecan may stabilize the fragile-site breakage of the RET oncogene and render cancer cells more sensitive to chemotherapy.
The protein - ASCL1 - is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET.
The research also showed that patients with ASCL1 tumors with high levels of the RET oncogene protein did not survive as long as ASCL1 patients with low levels of RET.
RET oncogene activation in papillary thyroid carcinoma.
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.
Molecular defects in thyroid carcinomas: role of the RET oncogene in thyroid neoplastic transformation.
1,2) The results of studies of RET oncogene expression further support the classification of WALTT as a papillary thyroid carcinoma.
Results are presented for analyses of SNPs in the FVII gene as an example; data for typing of [beta]-thalassemia and RET oncogene mutations are available as Data Supplements with the online version of this article.
The study has demonstrated that patients with ASCL1 tumours with high levels of the RET oncogene protein did not survive as long as ASCL1 patients with low levels of RET.
RET oncogene testing showed only normal sequences in exons 10, 11, and 13.