RELB

RELB

A gene on chromosome 19q13.32 that encodes a protein that binds to NFKB1 or NFKB2 to form the NFKB complex (the most abundant form is NFKB1/RELA), which is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); NFKBIA or NFKBIB inactivate the NFKB complex by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
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NF-?B1 or NF-?B2 is bound to REL (V-rel avian reticuloendotheliosis viral oncogene homolog), RELA , and RELB to form the NF-?B complex, which binds to the promoter regions of several genes, including those encoding TGF-[sz]1, AKR1B1 (aldo-keto reductase family 1, member B1), CCL2 (CC chemokine ligand 2), and ICAM1 (intercellular adhesion molecule 1).
SIRT1 remained promoter-bound and recruited de novo-induced RelB, which resulted in endotoxin tolerance [33].
[70] NF-[kappa]B is a dimer that results from the combination of a family of structurally related DNA-binding proteins: p65 (RelA), RelB, c-Rel-Rel, p50, and p52 that act as transcription factors.
The NF-[kappa]B family of proteins, RelA (p65), RelB, and c-Rel, and p100 and p105 which subsequently degrade to form p52 and p50, respectively, [50] are central to the regulation of inflammation [51].
Five NF[kappa]B protein members are expressed in mammalian cells, RelA (p65), RelB, c-Rel, NF[kappa]B1 (p50/105), and NF[kappa]B2 (p52/100) [39].
NF-[kappa] subunits (RelB or p52) were predicted key hubs in all reactivity groups except in MA chemicals.
They display a strong preference to certain NF-[kappa]B dimers, which are composed of RelA (p65), RelB, c-Rel, p50 (p105 precursor), p52 (p100 precursor), and Relish proteins by their homo- or heterodimerization.
Nair et al., "Decreased expression of the NF-KB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression," Respiratory Research, vol.
Nuclear factor kappa B (NF-[kappa]B) is considered a master regulator of inflammation, having five components: NF-[kappa]B1 (p50 and its precursor p105), NF-[kappa]B2 (p52 and its precursor p100), RelA (p65), RelB, and c-Rel.
Nuclear factor- (NF-) [kappa]B, is a member of the Rel family, which is composed of c-Rel, RelA (p65), RelB, p50, and p52 [39].
The NF-[kappa]B family is formed by several members, including NF-[kappa]B1 (p50/p105), NF-[kappa]B2 (p52/p100), p65 (RelA), RelB, and c-Rel (13).