RELB

RELB

A gene on chromosome 19q13.32 that encodes a protein that binds to NFKB1 or NFKB2 to form the NFKB complex (the most abundant form is NFKB1/RELA), which is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); NFKBIA or NFKBIB inactivate the NFKB complex by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
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They found that nuclear SIRT1 guides RELB to differentially induce SIRT3 expression and increase mitochondrial biogenesis.
found that SIRT1, RELB, and SIRT3 act in sequence to modify mitochondrial bioenergetics.
Total Tag SNPs Gene inclusion tag passing Gene SNPs inclusion criteria criteria AHRR 27 24 AIP/ARA9/XAP2 2 0 ARNT 5 4 Canonical AhR AhR 11 8 HSP90 6 4 p23/TGES3 4 4 ARNTL 19 14 CCNT1 3 3 DAP3 3 1 ESR1/ER-a 49 33 GTF2F1 3 1 GTF2F2 9 6 HIF1A/MOP1 6 2 NCOA1/SRC1/RIP160 11 6 NCOA2/SRC2 19 14 NEDD8 4 4 NR2F1 2 2 AhR interacting genes (Entrez Gene) NRIP1/RIP140 10 8 RB1 4 4 RELA/NFKB3 4 2 SMARCA4 10 6 SP1 4 4 SRC 14 10 TAF4 6 4 TAF6 6 4 TBP 6 3 XPO1 5 5 AR 2 0 CREB1 4 3 ERB/ESR2 16 12 GR/NR3C1 18 15 GSTCD 5 5 AhR interacting genes (STRING) GSTM1 1 0 MYC 6 5 PPARA 16 11 RELB 6 4 UGT1A5 16 10 CYP1A1 2 1 CYP1A2 2 1 Dioxin-induced genes CYP1B1 6 5 TP53 5 1 ARNT2 58 36 Genes associated with reproductive CYP17A1 6 4 outcomes: Sone and Yonemoto 2008 9q31.