Rosai-Dorfman disease

(redirected from RDD)
Also found in: Acronyms, Wikipedia.

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

a chronic disease occurring in children and characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.

Rosai-Dorfman disease

(rō′zī-dôrf′măn′, -mən)
n.
A chronic disease characterized by painless, massively enlarged cervical lymph nodes whose sinuses contain histiocytes that have engulfed lymphocytes and other cells. Extranodal involvement sometimes occurs.

Rosai-Dorfman disease

A rare, benign idiopathic condition characterised by bilateral cervical lymphadenopathy. It is most common in young black men and women, but may affect other ages and races; it may be extranodal. 

Clinical findings
Massive bilateral cervical lymphadenopathy, fever.

Lab
Leukocytosis, increased erythrocyte sedimentation rate, polyclonal hyperimmunoglobulinaemia.
 
Prognosis
Uncertain; most resolve spontaneously, but some are aggressive and ultimately fatal.

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

(sī'nŭs his'tē-ō-sī-tō'sis mas'iv limf-ad-ĕ-nop'ă-thē)
A chronic disease occurring in children characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.
Synonym(s): Rosai-Dorfman disease.

Rosai,

Juan, U.S. pathologist, 1941–.
Rosai-Dorfman disease - Synonym(s): sinus histiocytosis with massive lymphadenopathy
References in periodicals archive ?
The NST reported that two technicians of a company had claimed to have lost the RDD while transporting it non-stop from Seremban in Negri Sembilan to their office in Shah Alam, Selangor.
The etiology and pathogenesis of RDD are currently unknown, and the disease can easily be misdiagnosed.
RDD typically presents in pediatric patients with enlarged lymph nodes, fever, elevated WBC, and elevated ESR.
Due to the rarity of RDD or SHML, no definitive pathogenesis has been identified.
'I would urge you (PHE and RDD) to be more effective and efficient to achieve the assigned task,' he directed Fayaz Butt.
A review of RDD imaging manifestations in the head and neck at one institution over a 10-year period found 5 out of 13 head and neck RDD cases had extranodal disease in the paranasal sinuses.
The patients included 3 males and 2 females with a median age of 38 years (27-45 years) at RDD diagnosis.
The presence of emperipolesis, or the engulfment of lymphocytes and erythrocytes by histiocytes that express S-100, is considered diagnostic of RDD. [2] In this case, the authors lacked the facilities for testing an immunohistochemical stain for S-100 positivity in histiocytes, and therefore it was not done on this patient's biopsy.
Those who attended included, Senior Minister for Finance and Energy Syed Murad Ali Shah, Special Assistant to CM for PHE and RDD Fayaz Butt, Chief Secretary Siddique Memon, Additional Chief Secretary (Dev) Aijaz Ali Khan, Principal Secretary to CM Alamuddin Bullo, Secretary PHE and RDD Imran Atta Soomro, chief engineers PHE and RDD and other concerned staff.
RDD is a disease whose status is largely relegated to an intriguing intellectual curiosity.
This report provides comprehensive information on the current therapeutic developmental pipeline of RDD Pharma Ltd.'s, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
RDD is an idiopathic disease, but its occurrence has frequently been observed after infectious disease.