PDE6B(redirected from RD1)
Also found in: Acronyms.
PDE6BA gene on chromosome 5q31.2-q34 that encodes the beta subunit of a herterotrimeric (one alpha, one beta and two gamma subunits) cyclic nucleotide phosphodiesterase, which hydrolyses cGMP to 5'-GMP. Expressed in retinal rods, PDE6B is a key phototransduction enzyme in transmitting and amplifying visual signals.
PDE6B mutations are linked to retinitis pigmentosa and autosomal dominant congenital stationary night blindness.