PDE6B

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PDE6B

A gene on chromosome 5q31.2-q34 that encodes the beta subunit of a herterotrimeric (one alpha, one beta and two gamma subunits) cyclic nucleotide phosphodiesterase, which hydrolyses cGMP to 5'-GMP. Expressed in retinal rods, PDE6B is a key phototransduction enzyme in transmitting and amplifying visual signals.

Molecular pathology
PDE6B mutations are linked to retinitis pigmentosa and autosomal dominant congenital stationary night blindness.
References in periodicals archive ?
Following the US FDA's 510(k) clearance, the company will now launch its RD1 System device in the US market.
dentocariosa Rd1, assays of bacterial growth and survival were performed in presence of increasing concentrations of the extracts.
In our laboratory setting, we calculated the cost of each method as $ 2.0 with MALDI-TOF MS, $ 9.5 with PCR assay including tests for tul4 and RD1, and $ 14-16 when following a conventional identification algorithm.
The ratio first order derivative method (RD1) permits the determination of each component in their mixture at the wavelengths corresponding to a maximum or minimum.
Sahel, "Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina," Molecular Vision, vol.
Internal R&D (rd1): R&D activities that are performed by the firm itself to improve the accumulation of knowledge, or to use existing knowledge to generate new applications.
tb and BCG, of which one deletion, termed 'RD1', is absent from all BCG currently used as TB vaccines globally.
Se confirmo la identidad de la bacteria por la caracterizacion molecular con la tecnica de PCR con los oligonucleotidos universales FD1 y RD1, que amplifican el gen ADNr 16s (Rodrigues et al., 2003).
For asphalt road and roof (RD1, RD2, and RF1), the proportions of DCOD in TCOD were in the range from 71.76% to 86.23%.
Similarly, Rc1 and Rd1 were located as shown in Figures 3(c)-(d) after the DSIR of the previous channel has been posited.
Besides, HA2 and HA4, RD1 and RD4 yielded high secondary loadings onto a different factor.