RCC1


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RCC1

A gene on chromosome 1p36.1 that encodes a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. The RCC1 protein product helps regulate the onset of S-phase chromosome condensation, binding to nucleosomes and double-stranded DNA. The RCC1-Ran complex with other proteins is part of a signal transmission pathway that detects unreplicated DNA. RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
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(1991) Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354, 80-82.
(1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.
The observed increased expression of RCC1 is one of the most important members of the RAN signaling pathway, which is involved in the nucleocytoplasmic transport of macromolecules [64, 65].
Macara, "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B," Science, vol.
He said that RCC1 is fully aware of the importance of promotion of trade activities in the SAARC region.
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