KDM5A

(redirected from RBP2)
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KDM5A

A gene on chromosome 12p11 that encodes lysine-specific demethylase 5A, which is a ubiquitously expressed nuclear protein. It forms a complex with other proteins, binding to retinoblastoma protein and regulating cell proliferation.
References in periodicals archive ?
The H3K4me3 demethylase activity of RBP2 has also been demonstrated to contribute to regulating cell differentiation [20].
As described above, epigenetic or chromatin modifiers, such as histone demethylase RBP2 and the PcG protein complexes PRCs, are closely associated with pRB-mediated cell differentiation.
One example is that the expression of the H3K4me3 demethylase RBP2 was increased in lung cancer [110].
Dembski et al., "Characterization of the retinoblastoma binding proteins RBP1 and RBP2," Oncogene, vol.
Kaelin Jr., "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation," Molecular Cell, vol.
DeWaal et al., "Genomewide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation," Molecular Cell, vol.