RBL1

RBL1

A gene on chromosome 20q11.2 that encodes a key regulator of entry into cell division, which is directly involved in heterochromatin formation by maintaining overall chromatin structure and that of constitutive heterochromatin by stabilising histone methylation. RBL1 recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression; it is thought to be a tumour suppresor.
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In the cell cycle signaling pathway, we noted alteration in the expression Ccna2 Stag2, Atr, Smc1a and Rbl1 .
Endochondral Actin Focal TGF[beta] MAPK ossification cytoskeleton adhesion signaling signaling FGF2 FGF1 ITGA6 UCHL5 STMN1 TGFB2 FGF2 STYK1 CDC2 DUSP1 PLAT FGF5 CAV1 SMURF2 TRAF2 CALM1 FGF22 CAV2 NEDD9 BDNF ADAMTS1 KRAS CAV3 STAMBPL1 MAP3K5 OPG NRAS LAMC2 CCNB2 ACVR1C C11orf13 THBS1 RBL1 KRAS F2R PXN MAPK8 TGFB2 CRK RHOB PARD6A NRAS PAK1 PDPK1 CAV1 PPP5C ARHGEF7 MYLK2 TFDP1 PAK1 VIL2 PAK1 KLF6 CRK PXN MAPK8 FST MAPK8 BCL2 SERPINE1 CCND3 THBS1 CRK NOG HRAS Table 3: Genes involved in adipogenesis-related pathways that are upregulated in CYD-treated hMSCs.
Similarly, five genes including TOP2A, REL, SHH, ROS1, and CHEK2 in colon cancer gene network and three genes including RBL1, MAPK9, and PIK3CA in adenocarcinoma of lung gene network are selected.
[23] found that the expression levels of RBL1, a protein similar to that encoded by the gene pRb2, were negatively related to the histological stage and metastasis of lung tumors.
[54] have reported that CDK2 can catalyze the S964 site of protein RBL1 (P28749).
Ranking UniProtKB Protein name Site Score 1 Q08999 RBL2 S1035 0.4707 2 P28749 RBL1 S964 0.4672 3 P28749 RBL1 T369 0.4481 4 Q08999 RBL2 S672 0.4403 5 P28749 RBL1 S975 0.4389 6 Q08999 RBL2 T401 0.4313 7 Q9UQ35 SRRM2 T1413 0.3952 8 P49736 MCM2 S31 0.3736 9 Q9Y5N6 ORC6 T195 0.3717 10 P24928 POLR2A S1878 0.3663 11 Q15910 EZH2 T487 0.3653 12 Q9UQ35 SRRM2 T866 0.3553 13 O15446 CD3EAP S285 0.3505 14 P24928 POLR2A S1920 0.3495 15 P24928 POLR2A S1934 0.3492 16 Q02539 HIST1H1A S183 0.3488 17 P10276 RARA S77 0.3425 18 Q5TKA1 LIN9 T96 0.3412 19 Q9P1Z0 ZBTB4 T983 0.3347 20 P49736 MCM2 T59 0.3338 Figure 1: Construction of phosphorylation site-kinase network and extracting the pSKN profiles.
When reading 0, supposed that the value 0 will appeared on the RBL1, then the bit line RBL1 will discharging, due to the bit line voltage value is at the trip-point of the inverter, so the voltage gain is very big at this point.
There was significant correlation between CDK2 and RBL1 as well as MAX and MYC, although it was higher for the former ([r.sup.2] = 0.84 vs 0.58, respectively) (see online Supplemental Tab 6, C and D).
The probe-based assays targeting CDK2 and RBL1 recorded similar patterns, with the Cqs recorded for both targets lower in C71A (see online Supplemental Tab 13).
Using reverse transcription--(RT-) PCR arrays, they showed that human bone marrow MSC-derived EVs contain mRNAs involved in transcription (e.g., CLOCK, IRF6, and LHX6), immune regulation (e.g., CRLF1, IL1RN, and MT1X), cell cycle regulation (e.g., SENP2, RBL1, and CDC14B), DNA/RNA binding (e.g., HMGN4, TOPORS, and ESF1), actin cytoskeleton regulation (e.g., DDN, MSN, and CTNNA1), and extracellular matrix remodeling (e.g., COL4A2, IBSP) as well as cell differentiation into neuron (e.g., RAX2, OR11H12), bone (e.g., NIN, BMP15), endothelium/epithelium (e.g., MAGED2, CEACAM5), and hematopoietin (e.g., HK3, EPX).
For example, miR-335 could regulate 7 genes, namely, DCN, FST, THBS1, RBL1, ACVR2A, LTBP1, and BMPR2, while THBS1 was also regulated by miR-708, where the two miRNAs had different regulated directions in DFs (Figure 5).
It was demonstrated that the mRNAs present in EVs are associated with the mesenchymal phenotype and with several cell functions related to the control of cell differentiation (RAX2, OR11H12, OR2M3, DDN, and GRIN3A), transcription (CLOCK, IRF6, RAX2, TCFP2, and BCL6B), proliferation (SENP2, RBL1, CDC14B, and S100A13), cytoskeleton (DDN, MSN, and CTNNA1), metabolism (ADAM15, FUT3, ADM2, LTA4H, BDH2, and RAB5A) [47], and cell immune regulation (CRLF1, IL1RN, and MT1X) (Table 2).