RB1


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RB1

A gene on chromosome 13q14.2 that encodes a tumour suppressor protein which is a key regulator of entry into cell division, promoting G0-G1 transition following phosphorylation by CDK3/cyclin-C. RB1 represses transcription of E2F1 target genes. Underphosphorylated,
active forms of RB1 interact with E2F1 and repress its transcription activity, leading to cell cycle arrest. With calcium influx, RB1 is dephosphorylated by calcineurin, leading to release of the repressor complex.  

Molecular pathology
Defects in RB1 cause childhood retinoblastoma, some forms of osteogenic sarcoma and increased susceptibility to bladder cancer.
References in periodicals archive ?
Detection of mosaic RB1 mutations in families with retinoblastoma.
GE 17-7 has a strong ability to convert the major ginsenoside Rb1 and Rd into minor ginsenoside Rg3 via hydrolyzing the outer glycosidic linkage at C-20 position.
The mutations of 4 genes, including FGFR3, E74-like ETS transcription factor 3 (ELF3), cyclin-dependent kinase inhibitor (CDKN1A), and TSC complex subunit 1 (TSC1), were enriched in luminal tumors, while the basal tumors were enriched for the mutations of TP53, RB1, and nuclear factor erythroid-derived 2-like 2 (NFE2L2) genes.
Porque tem vezes que se a gente nao passar a cliente pode precisar e comprar de outra, entao e importante essa organizacao e esse acompanhamento" (RB2); "A estrategia, na real, e fidelizar a cliente mostrando pra ela que o produto e bom, dando amostras gratis pra ela experimentar e sentir que e bom mesmo e tambem se tornar fiel ao produto e a mim (risos)" (RB1).
The decreased expression of BDNF mRNA, found after the single prolonged stress, was significantly restored to normal level by chronic treatment with Rb1 (10 or 30 mg/kg, i.p., 14 days) or fluoxetine (10 mg/kg).
Matsuda et al., "Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root," Neuroscience Research, vol.
Huang, "Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet," PLoS One, vol.
Another study has shown that ginsenoside Rb1 activates the insulin signaling pathway, upregulates the expression and translocation of glucose transporters in adipose tissue, and thus increases glucose uptake in adipocytes, thereby reducing blood glucose levels and improving insulin resistance [88].
The rule block RB1 evaluates project status (PS) based on the Earned Value Management --EVM (Vanhoucke, 2014), specifically the indexes SPI and CPI.