RB gene


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Related to RB gene: retinoblastoma, p53, Retinoblastoma 1

RB gene

Tumor suppressor gene encoding for the retinoblastoma (RB) protein, mutations of which are associated with various human tumors, including retinoblastoma, osteosarcoma, some leukemias, and some adenocarcinomas.
See: tumor suppressor gene; retinoblastoma
See also: gene
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References in periodicals archive ?
LB, left border; RB gene, RB gene intron with a size of 679 bp; CDS, coding sequence of the RB gene with a size of 3,589 bp: pA Nos, poly-adenylation sequence of the nopaline synthase of A.
Callus formation of transformed leaves with RB gene of the events 54, 56, 65, 68, 69, 70 and 72.
* The genetics involves the Rb gene situated on chromosome 13, which is large, with 27 different sections.
However, it has been difficult to effectively track the RB gene in breeding populations that have not been exposed to late blight inoculation.
bulbocastanum somatic hybrids may contain any or all of the four RGA/rga sequences, the PCR marker for the RB gene must be specific to RB and distinguishable from rb as well as other RGA/rga sequences.
In addition, our findings of low expression of cyclin D1 in the absence of pRb expression are in accordance with results of other investigators, (33) confirming the essential requirement of functional Rb gene in cyclin D1 expression.
This suggests that problems with the RB gene are common for people with AML.
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.
The Rb gene is a tumor suppressor gene encoding a 110-kd nuclear phosphoprotein.
Scientists discovered years ago that retinoblastoma involves the failure of a particular gene, the RB gene, to function properly.
This form has been variously called blastic/blastoid variant of MCL or anaplastic variant of centrocytic lymphoma.[1,13-15] Recent studies have shown that p53 gene mutation or p53 protein overexpression occurs in approximately 50% of these aggressive variants of MCL.[16] In addition, abnormalities in the cell cycle inhibitory genes [p21.sup.WAF1] and [p16.sup.INK4a] have been reported in a few cases of blastoid MCL in one series.[17] Abnormalities of Rb gene structure do not appear to play a role in MCL (typical or blastoid).[11] In contrast to the findings in typical MCL, phosphorylated Rb has been identified in blastoid MCLs with a correspondingly high proliferation rate, suggesting that regulation of this part of the cell cycle pathway is intact.[11]
[10] Alterations of p53 and Rb genes have also been reported in AdCCs.