RANBP1

RANBP1

A gene on chromosome 22q11.21 that encodes a protein that binds to RAN complexed with GTP, markedly increasing GTP hydrolysis by the RanGTPase-activating protein. RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
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On the other hand, although Ran has its own weak hydrolytic activity, the hydrolysis of RanGTP to RanGDP is strongly accelerated by the GTPase-activating protein RanGAP1, in conjunction with Ran binding protein 1 (RanBP1) and/or Ran binding protein 2 (RanBP2, also called Nup358).
After translocation through the NPCs, the RanGTP/importin [beta]1 export complex and RanGTP/CAS/importin [alpha] export complex are dissociated through the conversion of RanGTP in these complexes to RanGDP by cytoplasmic RanGAP1 with the aid of RanBP1 and/or RanBP2.
Gene-encoding proteins implied that nucleo-cytoplasmic transport was also overexpressed (KPNA2, KPNB1, RANBP1, and RCC1).
Comparison with previous gene expression analysis of CRC that used tissue from the tumor as the source of RNA revealed that 4 of our differentially upregulated genes, PSAM3, RANBP1, GCLC, and KIAA0101, had been previously identified in 2 different studies as upregulated in CRC (12,13).