RAMP2


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RAMP2

A gene on chromosome 17q12-q21.1 that encodes one of the RAMP (receptor [calcitonin] activity-modifying protein) family of single-transmembrane-domain proteins, which are type-I transmembrane proteins needed to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on the expressed RAMP; in the presence of RAMP2, CRLR acts as an adrenomedullin-1 receptor.
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Effects of AM on IL-1[beta], AM, RAMP2, and RAMP3 Gene Expression in Synovial Fibroblasts and Macrophages.
Higher gene expression of the genes encoding CD11c, IL-1[beta], AM, RAMP2, and RAMP3 was also observed in ST from the dislocated side compared to control ST.
In the present study, the fibroblast cell fraction obtained from the inflamed ST of mice expressed significantly higher levels of RAMP2 compared to the macrophage cell fraction, consistent with a report in which RAMP2 was expressed in the synovial fibroblasts of RA patients [28].
Caption: Figure 2: Real-time polymerase chain reaction (PCR) analysis of interleukin- (IL-) 1[beta], adrenomedullin (AM), receptor activity-modifying protein 2 (RAMP2), and RAMP3 gene expression in the synovial tissue of C57BL/6J mice.
Caption: Figure 3: Real-time polymerase chain reaction (PCR) analysis for interleukin- (IL-) 1[beta], adrenomedullin (AM), receptor activity-modifying protein 2 (RAMP2), and RAMP3 gene expression in F4/80-negative and -positive cells derived from inflamed synovial tissue.