UBE2B

(redirected from RAD6B)

UBE2B

A gene on chromosome 5q31.1 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair.
References in periodicals archive ?
In humans, the yeast homologous Rad6 gene is duplicated and the proteins encoded by the two genes HHR6A (or Rad6A) and HHR6B (Rad6B) from chromosomes Xq24-q25 and 5q23-q31, respectively, share 95% identical amino acid residues [24].
Tait, "Rad6B is a positive regulator of [beta]-catenin stabilization," Cancer Research, vol.
Gerard, "Essential role of T-cell factor/[beta]-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells," Molecular Cancer Research, vol.
Shekhar, "Rad6B acts downstream of Wnt signaling to stabilize [beta]-catenin: implications for a novel Wnt/[beta]-catenin target," Journal of Molecular Signaling, vol.
Visscher, "Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response," Medical Oncology, vol.