Furthermore, and regarding radiation resistance, error-prone or error-free Rad6 and Rad18
dependent translesion synthesis (TLS) play an important role upon single and double strand breaks as well as upon base damage (21, 24, 30).
DNA repair array gene expression results showed that when this patient's results compare with the other NF1 patients without malignancy; ATR, CCNO, MLH1, NEIL1, NTHL1, RAD18, RAD 51, XRCC1, XRCC3 genes are overexpressed and ATM, BRCA1, BRCA2, ERCC4, EXO1, FEN1, LIG1, LIG3, MPG, MRE11A, MSH2, NEIL2, PMS1, POLD3, RFC1, SMUG1, TDG, TOP3B genes are down-regulated in this patient (mother).
PNKP, RAD18, XAB2, XRCC3, XRCC4 and XRCC5 genes were down-regulated compared with control group in her daughter.
Li, "Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer," Tumor Biology, vol.
miRNAs downregulated in chemoresistance to conventional drugs miR-22 5-FU BTG1 miR-34a 5-FU SIRT1, E2F3, KIT, LDHA miR-122 5-FU PKM2 miR-129 5-FU BCL2, TYMS, E2F3 miR-133a Oxaliplatin RFFL miR-139-5p 5-FU NOTCH1 miR-141/200c Oxaliplatin ZEB1 miR-143 5-FU, oxaliplatin BCL2, NFKB, ERK5, IGF1R miR-145 5-FU FLI-1, RAD18 miR-149 5-FU FOXM1 miR-153 Oxaliplatin FOXO3 miR-196a Oxaliplatin HOXA7, HOXB8, HOXC8, HOXD8 miR-200 cluster 5-FU EMT-related genes miR-203 5-FU TYMS miR-204 5-FU HMGA2 miR-222 Oxaliplatin ADAM17 miR-297 Oxaliplatin ABCC2 miR-451 Irinotecan ABCC1 miR-497 5-FU, irinotecan IGF1R miR-519c 5-FU, oxaliplatin ABCG2, ELAVL1 (HuR) miR-1915 Oxaliplatin BCL2 miRNAs overexpressed in chemoresistance to monoclonal antibody-based therapies miR-17-3p Cetuximab ?
The enzyme, known as Rad18
, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair.
Several DNA repair genes, MSH2, RAD18
, RAD51, RAD54, XRCC1, XRCC4, and XRCC5, and two apoptosis inducers, CASP3 and HCS, were also in this category.