RAD17

RAD17

A gene on chromosome 5q13 which encodes a protein that binds to chromatin before DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. RAD17 recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage. RAD17 phosphorylation is required for the DNA-damage-induced cell cycle G2 arrest, and is a critical early event during checkpoint signalling in DNA-damaged cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
HDF1 and RAD17 genes are involved in DNA double-strand break repair in stationary phase Saccharomyces cerevisiae.
Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genesin the repair of double-strand breaks in cycling cells.
Interestingly, microarray analysis of human MII oocytes recovered from aged versus young donors has also revealed that the former are characterised by an apparent decrease in several genes associated with the DNA damage checkpoint, including Atr, Chek1, Nbs1, and Rad17 [96].
Abraham, "Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling," The EMBO Journal, vol.
Protein function S.cerevisiae S.pombe Xenopus Mammals Sensors Rad24 Rad17 Rad17 Rad17 RFC-like Ddc1 Rad9 Rad9 Rad9 PCNA-like Mec3 Hus1 Hus1 Hus1 Rad17 Rad1 Rad1 Rad1 P13-Kinases (PIKK) Tel1 Tel1 ATM ATM Med Rad3 ATR ATR PIKK binding partner Ddc2 Rad26 ???