RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release.
Three-dimensional fibroblast-tumor cell interaction causes downregulation of RACK1 mRNA expression in breast cancer cells in vitro .
P Huang et al., "RACK1
and stratifin target [DELTA]Np63[alpha] for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage," Cell Cycle, vol.
This increase involved a regulatory mechanism mediated by RACK1 because exogenous increases in RACK1 led to increased BDNF expression, resulting in reduced ethanol consumption (McGough et al.
Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. Journal of Biological Chemistry 285(25):19043-19050, 2010.
Semenza, "RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha," Molecular Cell, vol.
Effectors HIF-1[alpha] HIF-1[alpha] References stabilizer destabilizer Oxygen [check]  2-OG (2-oxoglutarate) [check]  Hypoxia [check]  Hyperoxia [check]*  iNOS-derived NO [check]  RACK1 [check]  HSP90 [check]  ROS [check] [81, 82] HIF-1[alpha]: Hypoxia-inducible factor-1[alpha]; HSP90: Heat shock protein 90; iNOS: Inducible nitric oxide synthase; RACK1: Receptor for activated C kinase 1; ROS: Reactive oxygen species.
Interaction of "readthrough" acetylcholinesterase with RACK1
and PKC[beta]II correlates with intensified fear-induced conflict behavior.
Coffer, "Association of RACK1
and PKCbeta with the common beta-chain of the IL-5/IL-3/GMCSF receptor," Oncogene, vol.
, a PKC targeting protein, is exclusively localized to basal airway epithelial cells," Journal of Histochemistry and Cytochemistry, vol.