RAB8A

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RAB8A

A gene on chromosome 19p13.1 that encodes a member of the Rab subfamily of Ras-related small GTPases, which may play a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus and plasma membrane.

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Important mediators of this pathway are proteins necessary for plasma membrane fusion like Rab8a [64, 69], Sec22b, SNAP23/29, and STX3/4 [66]; absence of STX17 [66], which is necessary for fusion with the lysosome and GRASP proteins [64, 67]; and possibly peroxisomal signaling [61, 67] (Figure 2).

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

Klip, "Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells," Proceedings of the National Academy of Sciences of the United States of America, vol.