Wanget al., "Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A
and ATG4D expression in glioma," Biochemical and Biophysical Research Communications, vol.
The docking of MVB with the PM is mediated by several components of the RAB family of small GTPase proteins (RAB2B, RAB5A
, RAB7, RAB9A, RAB11, RAB27A, RAB27B, RAB35 , and RLP-1 ).
It was demonstrated that the mRNAs present in EVs are associated with the mesenchymal phenotype and with several cell functions related to the control of cell differentiation (RAX2, OR11H12, OR2M3, DDN, and GRIN3A), transcription (CLOCK, IRF6, RAX2, TCFP2, and BCL6B), proliferation (SENP2, RBL1, CDC14B, and S100A13), cytoskeleton (DDN, MSN, and CTNNA1), metabolism (ADAM15, FUT3, ADM2, LTA4H, BDH2, and RAB5A
) , and cell immune regulation (CRLF1, IL1RN, and MT1X) (Table 2).
The phase of vesicle initiation was suppressed by miR-30a/b, miR-376b, miR-17-5p, and miR-216a [129-132] inhibiting BECLIN1 expression; by miR-152  that targets ATG14; by miR-101  downregulating RAB5A
; and by miR-24-3p, miR-376b, miR-101, and miR-34a [130, 134-136] that modulates ATG4.
12 proteins were identified, associated with this cell process, which were SEC22B (Sec22), TUBB (TUBB), ITGA5 ([alpha]5[beta]1), ACTB (F-actin), ITGB2 (CR3), ITGB1 ([beta]1), TUBA1B (TUBA), ATB6V1B2 (vATPase), SEC22B (Sec22), CANX (calnexin), RAB5A
(Rab5), and FCAR (FcaR) (Figure 6).
The small GTPases Rab5a
, Rab5b and Rab5c are differentially phosphorylated in vitro.
Wada et al., "Expression of Rab5a
in hepatocellular carcinoma: possible involvement in epidermal growth factor signaling," Hepatology Research, vol.
Chou, "Insight into the molecular switch mechanism of human Rab5a
from molecular dynamics simulations," Biochemical and Biophysical Research Communications, vol.
Khan et al., "Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a
, and phosphatidylinositol 3-kinase in human neutrophils," Journal of Immunology, vol.