Immunomodulatory molecules, HOXB4, CD81, CD9, TGF-[beta]1, IDO, Notch1, ADAM17, Rab4
, and HGF, were also found by LC/MS/MS in addition to MHC Class I and II antigens.
In addition, other Rabs that are implicated in intracellular GLUT4 traffic include Rab4 , Rab5 , Rab11 , Rab28 , and Rab31 .
The connection of aPKC signal to GLUT4 vesicle trafficking appears to involve the actin cytoskeleton, Rabs, and molecular motors, as PKC[lambda]/[zeta] can impinge on Rac-mediated actin dynamics and can also regulate the interaction between Rab4 and kinesin motors [72, 73].
Le Marchand-Brustel, "Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes," Molecular and Cellular Biology, vol.
Insulin-induced GLUT4 translocation involves protein kinase C-[lambda]-mediated functional coupling between Rab4 and the motor protein kinesin.
Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.
and Rab5 null mutants were no longer able to support the intemalization of the Leishmania adenosine permease by TOR.
Additionally, mTOR controls the expression of the TCR-associated signaling protein CD4, and through increased expression of the endosome recycling regulator HRES-1/ Rab4
, mTOR mediates enhanced [Ca.sup.2+] flux, skews the expression of tyrosine kinases in T cells, and blocks the expression of Foxp3 and the expansion of regulatory cells [31, 32].
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4
and the motor protein kinesin.