Similarly, M3 includes several genes whose products are involved in membrane fusion, synaptic exocytosis, and presynaptic dynamics , including SNARES (Vamp2, Vamp3, and Stx1A), STX binding proteins (Stxbp1 and Stxbp5), and Rab signaling molecules (Rab3a
and Rims1), which may account for synaptic effects induced by the crosstalk between canonical Wnt pathway and calcium signaling components and that may be important in synaptic dysfunction disorders.
Among the other direct targets genes there are insulin itself and components of the exocytosis apparatus such as Rab3A
and Rab27A, which are members of the Rab family, and two of their effectors, slp4 and Noc2 [23,24].
There, the protein can modulate synaptic dopamine release by directly modulating the dopamine transporter (DAT), synapsin III, the small GTP-binding protein Rab3A
, and the soluble N-ethylmaleimide sensitive fusion attachment protein receptor (SNARE) protein member vesicle associated membrane protein-2 (VAMP2) .
Purification of squid synaptic vesicles and characterization of the vesicle-associated proteins synaptobrevin and Rab3A
, Brain Res.
ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder; AZ, active zone; BPD, bipolar disorder; MDD, major depressive disorder; NRXN, neurexin; RIM, Rab3a
interacting molecule; SCZ, schizophrenia; SynCAMs, Synaptic adhesion molecules; SV, synaptic vesicle.
The members of the Rab family of proteins responsible for myosin-V recruitment to neuronal vesicles in the squid nervous system have not been determined, although Rab3a
is known to be associated with synaptic vesides in squid brain (6).