Many other genes might also be involved in the pathogenesis of UM such as the Ras and EF-hand domain containing (RASEF) gene, RAB31, hTERT, embryonal fyn-associated substrate, and deleted in split-hand/split-foot 1.
The extensive promoter hypermethylation was also observed in an independent cohort of 67 UM samples. Interestingly, the study found that out of the 12 genes that were previously reported to be associated with metastatic risk of UM. Only RAB31 , a member of the RAS oncogene family, showed differential methylation between normal uvea and UM.
Soelch et al., "Inverse association of rab31
and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis," American Journal of Cancer Research, vol.
In addition, other Rabs that are implicated in intracellular GLUT4 traffic include Rab4 , Rab5 , Rab11 , Rab28 , and Rab31 .
Chang et al., "Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes," Cell Metabolism, vol.
Autophagy-associated proteins Rab1a and Rab31
were identified as targets of both miRNAs.