RAB25

RAB25

A gene on chromosome 1q22 that encodes a member of the Rab subfamily of Ras-related small GTPases, which mediates intracellular protein and membrane trafficking and regulation of cell survival.

Molecular pathology
RAB25 increases the rates of ovarian and breast cancers’ progression and aggressiveness by modulating proliferation, survival and migration of tumour cells.
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References in periodicals archive ?
Kuo et al., "The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers," Nature Medicine, vol.
Pei et al., "Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis," Tumor Biology, vol.
Rab25, for instance, has been demonstrated to inhibit apoptosis as well as promote the proliferation and aggressiveness of ovarian and breast cancer [23, 24].
It has been widely reported that Rab proteins of the endocytic pathway (e.g., Rab25, Rab13, Rab23, and Rab5) and the constitutive secretory pathway (e.g., Rab8) play significant roles in malignancy [20, 27-30].