Hypoxia-inducible factors and RAB22A
mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
The fourteen DEGs identified by our analysis (SKIV2L2: Hs00299011_ml, SRPRB: Hs00253639_ml, JUNB: Hs00357891_sl, BNIP3: Hs00969291_ml, RAB22A
: Hs00221082_ml, TMED2: Hs00607277_ml, ACAT1: Hs00608002_ ml, NDUFV2: Hs00221478_ml, LBR: Hs01032700_ml, NCL: Hs01066668_ml, AAAS: Hs00210351_ml, ATXN2: Hs00268077_ml, LGMN: Hs00271599_ml, and CDKN1B: Hs00153277_ml) were also analyzed and validated by realtime quantitative PCR.
identified that ubiquit-inspecific peptidase 47 (USP47) and Ras-related protein Rab22A (RAB22A) were direct functional targets of miR-204-5p in GC and that miR-204-5p inhibited GC cell proliferation by downregulating USP47 and RAB22A .
Hu et al., "MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A," Medical Oncology, vol.
UCA1, upregulated in CRC, inhibited miR-204-5p activity, thus promoting the upregulation of miRNA targets CREB1, BCL2, and RAB22A
, member RAS oncogene) and regulating cell proliferation and apoptosis .
The fusion of autophagosome-lysosome fusion is mediated by key autophagic proteins such as RAB1B, RAB22A
, RAB14, RAB27A, LAMP2, and LAMP3.
(2012) 11 Composite population DACH1 Schneider et al.
 identified miR-373-3p as a tumor suppressor that directly targets the Rab22a oncogene in ovarian cancer.
Chen et al., "MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer," Oncotarget, vol.
[Source:RefSeq mRNA;Acc:NM_001114672] ENSSSCG00000007 513 RAB22A
Sus scrofa RAB22A
, member RAS oncogene family (RAB22A
USP47, RAB22A, SIRT1, Snai1, and so forth are targets of miR-204 that mediate miR-204 reducing the oncogenicity of gastric cancer [11, 22, 23].
Previous studies showed that miR-204 suppressed gastric cancer through targeting USP47, RAB22A, SIRT1, Snai1, and so forth [11, 22, 23].