Aberrant expression of RAB1A
in human tongue cancer.
The important regulators of these genes were insulin (P < 1.05[E-.sup.09]), melatonin (P < 1.41[E.sup.-09]), glucocorticoid (P < 5.83[E.sup.-09]), lithium (P < 1.45[E.sup.-08]), and RAB1A
(P < 5.48[E.sup.-08]).
Autophagy-associated proteins Rab1a and Rab31 were identified as targets of both miRNAs.
Chen et al., "miR-184 and miR-150 promote renal glomerular mesangial cell aging by targeting Rab1a and Rab31," Experimental Cell Research, vol.
Similarly, antagonist of miR-101 attenuates experimental cardiac hypertrophy by target the expression of ras-related protein-1A (Rab1A) .
Zhou et al., "MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a," Journal of Cardiovascular Pharmacology, vol.
MiR-221 promotesthe development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A
. Oncogene 2014; 33:2790-800.