microRNA-30b/c inhibits nonsmall cell lung cancer cell proliferation by targeting Rab18
. BMC Cancer 2014; 14: 126-136, doi: 10.1186/1471-2407-14-703.
Different proteins have been identified by proteomic analysis, mostly classified into three groups: (1) structural proteins, such as the members of the PAT (perilipin-ADRP-TIP47) family and the cell death-inducing DFF45-like effector (CIDE) family; (2) membrane-trafficking proteins, including but not limited to Rab10, Rab18, Rab32, and Arf1 proteins and soluble NSF attachment protein receptors (SNAREs); and (3) enzymes implicated in lipid synthesis, such as DGAT2, and catabolism, such as ATGL and HSL [8, 25].
In this context, Rab GTPases are the most abundant class of proteins associated to LDs, even though, only for some of them, such as Rab1, Rab5, Rab10, Rab18, and Rab32, a functional interaction with LDs has been reported [68, 71].
In the transgenic Arabidopsis, overexpression of AtHD2C was associated with enhanced expression of RD29B and RAB18
(ABA-responsive LEA-like genes) which resulted in tolerance of the transgenic plant to salt stress (Sridha and Wu 2006).
The promoters of many COR genes such as COR15a/b (Wilhelm and Thomashow, 1993; Baker et al., 1994), RAB18
(Lang and Palva, 1992), COR78 (Yamaguchi-Shinozaki and Shinozaki, 1993), KIN1/2 (Kurkela and Franck, 1990; Kurkela and Borg-Franck, 1992) from A.
PPARg continues being the central actor of the scene, but the dysfunction of many others has been recognized as part/cause of the development of these diseases; some of them belong to the lipogenesis pathway (FASN, FABP4, and SCD1) and others used to be associated with other roles (ZAG, RORa1, Rab18
, and BrCa1), but now their roles in this dysfunction are emerging.
###CaMV 35S-CmMYB2###Tolerance to drought and salt stress###Delayed in flowering###RD22 RD29A RAB18
COR47###Shan et al.
SW13 subunit of SW1/SNF complex has been recently reported to act as a positive regulator in ABA-mediated inhibition of seed germination and growth by interacting with a negative regulator, HAB1 (Hypersensitive to ABA1), to increase the expression of RAB18
and RD29B .
Constitutive overexpression of ABF3 and ABREB2 (=ABF4) in Arabidopsis enhance expression levels of target LEA-type genes (RAB18
The study revealed that MG had no effect on transcription of RD29A in either plant type, but significantly increased the transcription of RD29B and RAB18
, in a concentration-dependent manner.
In Arabidopsis, AtABI5 overexpression can induce RAB18
and some downstream stress-response genes (Brocard et al., 2002).
Role of abscisic acid in drought-induced freezing tolerance, cold acclimation, and accumulation of LTI78 and RAB18
proteins in Arabidopsis thaliana.