RAB14

RAB14

A gene on chromosome 9q32-q34.11 that encodes a member of the Rab subfamily of Ras-related small GTPases, which is involved in intracellular membrane trafficking. It acts as a molecular switch that flips between an inactive GDP-bound state and an active GTP-bound state, recruiting downstream effector proteins onto (endosomal, Golgi, cytoplasmic) membranes.
References in periodicals archive ?
In adipocytes, the Rab proteins that are currently considered to be the main targets of AS160 are Rab10 and Rab14 [49, 51].
Mastick, "Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes," The Biochemical Journal, vol.
In these cells, miR-205 downregulation determined radioresistance by targeting of PTEN [12], miR-451 increases radiosensitivity by targeting RAB14 (RAS related protein 14) [5], miR-23a is associated with modulation of radioresistance by targeting IL8 [13], and miR-185-3p regulates radioresistance, similar to miR-324-3p, by targeting WNT2B [23].
Liu et al., "MiR-451 increases radiosensitivity of nasopharyngeal carcinoma cells by targeting ras-related protein 14 (RAB14)," Tumor Biology, vol.
The fusion of autophagosome-lysosome fusion is mediated by key autophagic proteins such as RAB1B, RAB22A, RAB14, RAB27A, LAMP2, and LAMP3.
Chen, "MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14)," Oncogene, vol.
En la segunda fase, con las 27 proteinas extraidas (NTRK1, ELAVL1, RAB5A, GTSE1, OCRL, NXF1, GRB2, CLTC, RAB8A, RAB1A, RAB6A, SSX2IP, XPO1, FAM109A, FAM109B, SPINT2, GOLGA5, CEP128, SCLT1, CEP170, HERC2, SCN2B, ENPP6, VSIG4, BTN2A1, CACNG4, RAB14), se construyo una red de interaccion en el Software Cytoscape version 3.3.0 (Shannon, et al., 2003).
Categoria p-val Nodos Transporte mediado por 2.7482E-07 RAB1A GOLGA5 RAB14 CLTC vesiculas [GO:16192] GRB2 RAB6A RAB5A RAB8A Transduccion de senales 7.06E-06 RAB1A RAB14 GRB2 RAB6A mediada por pequenas RAB5A RAB8A GTPasas [GO: 7264] Vesiculas asociadas a Golgi 1.5258E-05 GOLGA5 RAB14 CLTC OCRL [GO: 5798] Membrane-bounded vesicle 2.9710E-05 GOLGA5 RAB14 CLTC OCRL GRB2 [GO: 31988] RAB5A APPL1 Vesiculas [GO: 31982] 4.8371E-05 GOLGA5 RAB14 CLTC OCRL GRB2 RAB5A APPL1 Internalizacion de 8.5044E-05 CLTC GRB2 RAB5A receptores [GO: 31623] Tabla 4.