RAB11A

RAB11A

A gene on chromosome 15q22.31 that encodes a member of the Rab subfamily of Ras-related small GTPases, which is part of the constitutive and regulated secretory pathways and is involved in protein transport.
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For example, overexpression of Rab11a increases expression of LC3II and beclin-1 in renal ischemia.
Xu, "MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/ reperfusion," Experimental Cell Research, vol.
The recommended markers are: DOK, (79) Rab11a, (80) P53, (81) POE9n, (82) Bcl2, (83) and CD44.
Furthermore, we have observed the gene expression pattern of farnesyl pyrophosphate synthase (FDPS), farnesyl-diphosphate farnesyl transferase 1 (FDFT1), caspase 7 (CASP7), Rho family GTPase (RND3), Ras oncogene family member (RAB11A), and DNA methyl transferase 1 (DNMT1) in ALN treated and control Huh-7 cells.
PCR was performed to amplify the transcript of the Human FDPS, FDFT1, CASP7, RAB11A, RND3, and DNMT1 genes using oligonucleotide primers.
Expression levels of RAB11A, RND3, and DNMT1 were also decreased in treated cells as compared to untreated cells.
To examine the effect of ALN on protein prenylation, expression of RAB11A and RND3 genes (corresponding to Rho and Ras protein families resp.) was studied which was found to be decreased.
Rab11a and myosinVb are required for polarization of WIF-B9 cells.
These genes include protein kinases (AKT, MEK1, PIM3), growth factors (VEGF, PLGF), GTPases (RHOC, RAB11A, DEXRAS1), cytokine signaling proteins (MCP1, SOCS1, SOCS3, WSB1, IL17R), and a Wnt signaling factor (WNT4).
Shi et al., "Rab11a and HSP90 regulate recycling of extracellular [alpha]-synuclein," Journal of Neuroscience, vol.