miRNAs Target Gene description PSMB5 Proteasome (prosome, macropain) subunit, beta type 5 KIF3B Kinesin family member 3B hsa-miR-127-3p ITGA6 Integrin, alpha 6 BCAS3 Breast carcinoma-amplified sequence 3 MTSS1L Metastasis suppressor 1-like SP3 Sp3 transcription factor MYCBP2 MYC-binding protein 2, E3 ubiquitin protein ligase hsa-miR-493-5p TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG box) UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 HIPK1 Homeodomain-interacting protein kinase 1 RAB10 RAB10
, member RAS oncogene family UBE2D2 Ubiquitin-conjugating enzyme E2D 2 hsa-miR-409-3p KANSL1 KAT8 regulatory NSL complex subunit 1 MTF2 Metal response element binding transcription factor 2 ELF2 E74-like factor 2 (ETS domain transcription factor)
AS160 is a GTPase-activating protein that inhibits activity of Rab10
and intracellular traffic of GLUT4-containing vesicles.
delivers GLUT4 storage vesicles to the plasma membrane," Communicative and Integrative Biology, vol.
In adipocytes, the Rab proteins that are currently considered to be the main targets of AS160 are Rab10 and Rab14 [49, 51].
Teruel et al., "Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane," Cell Metabolism, vol.
Zhang et al., "Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes," The Journal of Cell Biology, vol.
Different proteins have been identified by proteomic analysis, mostly classified into three groups: (1) structural proteins, such as the members of the PAT (perilipin-ADRP-TIP47) family and the cell death-inducing DFF45-like effector (CIDE) family; (2) membrane-trafficking proteins, including but not limited to Rab10, Rab18, Rab32, and Arf1 proteins and soluble NSF attachment protein receptors (SNAREs); and (3) enzymes implicated in lipid synthesis, such as DGAT2, and catabolism, such as ATGL and HSL [8, 25].
In this context, Rab GTPases are the most abundant class of proteins associated to LDs, even though, only for some of them, such as Rab1, Rab5, Rab10, Rab18, and Rab32, a functional interaction with LDs has been reported [68, 71].
miRNA Function Putative targets Reference miR-17-92 Down-regulated in IRF9, RAB10
,  imatinib treated TXNIP, TET2 CML cells miR-21 Antisense TXPAN2, LUM,  inhibition leads SUZ12, MSH2, to inhibition of PDZD2 migration and cell growth and induces apoptosis miR-203 Methylated in AML, RTKN2, AAK1,  CML, ALL, CLL.
That's why the discovery of the protein Rab10 by Weill Cornell Medical College scientists represents an encouraging step toward the prevention or improved treatment of diabetes.
"This is an important advance," says Timothy McGraw, MD, professor of biochemistry at Weill Cornell Medical College and co-author of the Rab10 study.
Rab10 helps the insulin signal a special glucose transporter, called GLUT4, to help move the glucose from the blood to the surface of the cells; if it's not functioning, blood sugar levels stay high and complications follow.