(7) When such complexes are taken up by phagocytes in the joint, they form the "RA cell," a cell analogous to the LE cell of Hargraves.
Table 1 Comparison of Immune Complex Formation in the Autoimmune Diseases Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) Immune response RA SLE Diagnostic RA cell (phagocytes LE cell (phagocytes tell-tale cell with ingested with ingested cell rheumatoid factor nuclei) complexes) Antigen Hinge region of IgG DNA, histones, etc.
The synovial fluid is rich in the RA cell
, which is a polymorphonuclear leukocyte that has encountered and engulfed immune complexes and complement.
While several RA cell
types contribute to cartilage and bone destruction, including neutrophils (in the joint space itself) and chondrocytes (sequestered deep within the cartilage), the primary cells that propagate articular damage at the pannus's leading edge are osteoclasts and synovial fibroblasts (SF).
To explore expression differences between normal and RA cells
, we first screened datasets that met the needs of our design by literature mining in the Gene Expression Omnibus (GEO) database.
Furthermore, they demonstrated that the oxidation of TrxR1 was irreversible by the addition of NADPH in RA cells
incubated for long periods.